Formulation and production of a novel pharmaceutical substance for treatment of infected wounds - A chitosan chymopsin complex
Brkich L. L., Salnikova T. S., Brkich G. E`., Belov A. A., Pyatigorskaya N. V.
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue6, P. 1310-1313
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Wound infection represent a serious threat to wounded patients all over the world. Untreated wounds may result in bacterial wound infections, such as gas gangrene and tetanus. These in turn may lead to long term disabilities, chronic wound or bone infection, and, ultimately, death. Appropriate management of infected wounds is important to reduce the likelihood of life-threatening complications. Chitosan chymopsin complex (CCC) is a novel pharmaceutical substance consisting of chymopsin (a combination of two proteolytic enzymes: trypsin and chymotrypsin) and acid-soluble chitosan (a natural high molecular weight polysaccharide). This substance, either alone or together with antiseptic and/or anesthetic agents, can be used in treatment of infected wounds of different etiology. Synthesis, and production of active pharmaceutical ingredients (API) using biotechnological methods are the most demanding and costly stages of drug manufacturing. Therefore, a thoughtfully performed formulation ca
Ключевые слова:
Active pharmaceutical ingredient; Chitin deacetylation; Chitosan chymopsin complex (ССС); Crab hepatopancreas; Infected wounds treatment; Polyelectrolyte complex (PEC); Proteolytic complex (PC); Proteolytic unit (PU)
chitosan; chitosan chymopsin complex; polyelectrolyte; unclassified drug; Article; drug formulation; drug manufacture; encapsulation; enzyme inactivation; enzyme stability; freeze drying; human; protein stability; thermodynamics; thermostability; wound infection
Язык текста: Английский
ISSN: 0975-1459
Brkich L. L. Liliana Lyubanovna 1990-
Salnikova T. S.
Brkich G. E`. Galina E`duardovna 1967-
Belov A. A.
Pyatigorskaya N. V. Natal`ya Valeryevna 1965-
Бркич Л. Л. Лилиана Любановна 1990-
Салникова Т. С.
Бркич Г. Э. Галина Эдуардовна 1967-
Белов А. А.
Пятигорская Н. В. Наталья Валерьевна 1965-
Formulation and production of a novel pharmaceutical substance for treatment of infected wounds - A chitosan chymopsin complex
Текст визуальный непосредственный
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue6 P. 1310-1313
2018
Статья
Active pharmaceutical ingredient Chitin deacetylation Chitosan chymopsin complex (ССС) Crab hepatopancreas Infected wounds treatment Polyelectrolyte complex (PEC) Proteolytic complex (PC) Proteolytic unit (PU)
chitosan chitosan chymopsin complex polyelectrolyte unclassified drug Article drug formulation drug manufacture encapsulation enzyme inactivation enzyme stability freeze drying human protein stability thermodynamics thermostability wound infection
Wound infection represent a serious threat to wounded patients all over the world. Untreated wounds may result in bacterial wound infections, such as gas gangrene and tetanus. These in turn may lead to long term disabilities, chronic wound or bone infection, and, ultimately, death. Appropriate management of infected wounds is important to reduce the likelihood of life-threatening complications. Chitosan chymopsin complex (CCC) is a novel pharmaceutical substance consisting of chymopsin (a combination of two proteolytic enzymes: trypsin and chymotrypsin) and acid-soluble chitosan (a natural high molecular weight polysaccharide). This substance, either alone or together with antiseptic and/or anesthetic agents, can be used in treatment of infected wounds of different etiology. Synthesis, and production of active pharmaceutical ingredients (API) using biotechnological methods are the most demanding and costly stages of drug manufacturing. Therefore, a thoughtfully performed formulation ca