Аннотация:
Brain tumors are characterized by very high mortality and, despite the continuous research on new pharmacological interventions, little therapeutic progress has been made. One of the main obstacles to improve current treatments is represented by the impermeability of the blood vessels residing within nervous tissue as well as of the new vascular net generating from the tumor, commonly referred to as blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB), respectively. In this review, we focused on established and emerging strategies to overcome the blood-brain barrier to increase drug delivery for brain cancer. To date, there are three broad strategies being investigated to cross the brain vascular wall and they are conceived to breach, bypass, and negotiate the access to the nervous tissue. In this paper, we summarized these approaches highlighting their working mechanism and their potential impact on the quality of life of the patients as well as their current status of devel
Ключевые слова:
Blood-brain barrier; Brain cancer; CED; Drug delivery; FUS; Nanomedicine
adsorptive mediated transcytosis; astrocyte; biodegradability; biological model; blood brain barrier; blood vessel wall; brain blood vessel; brain cancer; cancer mortality; cancer patient; drug delivery system; endothelium cell; human; in vitro study; in vivo study; membrane permeability; microglia; nanomedicine; nerve cell; neuroanatomy; nonhuman; pericyte; photodynamic therapy; quality of life; receptor mediated transcytosis; Review; tight junction; transcytosis; transporter mediated transcytosis; ultrasound; vascular endothelium
Parodi A. Alessandro 1978-
Rudzhin`ska M. Magdalena 1986-
Devyatkin A. A. Andrej Andreevich 1990-
Sund S. M. Surinder Mokhan 1969-
Baldin A. V. Aleksej Viktorovich 1992-
Zamyatnin A. A. Andrej Aleksandrovich 1976-
Пароди А. Алессандро 1978-
Руджиньска М. Магдалена 1986-
Девяткин А. А. Андрей Андреевич 1990-
Сунд С. М. Суриндер Мохан 1969-
Балдин А. В. Алексей Викторович 1992-
Замятнин А. А. Андрей Александрович 1976-
Established and emerging strategies for drug delivery across the blood-brain barrier in brain cancer
Текст визуальный непосредственный
Pharmaceutics
Vol.11, Issue5 Num.245
2019
Обзор
Blood-brain barrier Brain cancer CED Drug delivery FUS Nanomedicine
adsorptive mediated transcytosis astrocyte biodegradability biological model blood brain barrier blood vessel wall brain blood vessel brain cancer cancer mortality cancer patient drug delivery system endothelium cell human in vitro study in vivo study membrane permeability microglia nanomedicine nerve cell neuroanatomy nonhuman pericyte photodynamic therapy quality of life receptor mediated transcytosis Review tight junction transcytosis transporter mediated transcytosis ultrasound vascular endothelium
Brain tumors are characterized by very high mortality and, despite the continuous research on new pharmacological interventions, little therapeutic progress has been made. One of the main obstacles to improve current treatments is represented by the impermeability of the blood vessels residing within nervous tissue as well as of the new vascular net generating from the tumor, commonly referred to as blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB), respectively. In this review, we focused on established and emerging strategies to overcome the blood-brain barrier to increase drug delivery for brain cancer. To date, there are three broad strategies being investigated to cross the brain vascular wall and they are conceived to breach, bypass, and negotiate the access to the nervous tissue. In this paper, we summarized these approaches highlighting their working mechanism and their potential impact on the quality of life of the patients as well as their current status of devel