Current Molecular Pharmacology
Vol.12, Issue3, P. 202-214
Аннотация:
Background: Targeting of drugs to the subcellular compartments represents one of the modern trends in molecular pharmacology. The approach for targeting mitochondria was developed nearly 50 years ago, but only in the last decade has it started to become widely used for delivering drugs. A number of pathologies are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory and metabolic conditions. Objective: This mini-review aims to highlight the role of mitochondria in pathophysiological conditions and diseases, to classify and summarize our knowledge about targeting mitochondria and to review the most important preclinical and clinical data relating to the antioxidant lipophilic cations MitoQ and SkQ1. Methods: This is a review of available information in the PubMed and Clinical Trials databases (US National Library of Medicine) with no limiting period. Results and Conclusion: Mitochondria play an important role in the pathogenesis of many disease
Ключевые слова:
Antioxidants; Metabolic syndrome; Mitochondria; Reactive oxygen species; Targeted drug delivery; Uncouplers of oxidative phosphorylation
acetylcysteine; antioxidant; ascorbic acid; berberine derivative; cell penetrating peptide; cyanine dye; dequalinium; elamipretide; glutathione; placebo; pyridinium derivative; quaternary ammonium derivative; reactive oxygen metabolite; rhodamine; signal peptide; skq 1; triphenylphosphonium; ubidecarenone; unclassified drug; 10-(6'-plastoquinonyl)decyltriphenylphosphonium; 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide; antioxidant; organophosphorus compound; plastoquinone; reactive oxygen metabolite; ubiquinone; aging; Alzheimer disease; amyotrophic lateral sclerosis; antioxidant activity; Article; chronic hepatitis C; chronic kidney failure; chronic obstructive lung disease; diastolic dysfunction; disorders of mitochondrial functions; drug structure; drug targeting; Duchenne muscular dystrophy; fatigue; heart failure; human; Huntington chorea; hypertension; hypogonadism; inclusion body myositis; keratoconjunctivitis sicca; maximum plasma concentration; metabolic syndrome X; mit
Zinovkin R. A. Roman Alekseevich 1973-
Zamyatnin A. A. Andrej Aleksandrovich 1976-
Зиновкин Р. А. Роман Алексеевич 1973-
Замятнин А. А. Андрей Александрович 1976-
Mitochondria-targeted drugs
Текст визуальный непосредственный
Current Molecular Pharmacology
Vol.12, Issue3 P. 202-214
2019
Статья
Antioxidants Metabolic syndrome Mitochondria Reactive oxygen species Targeted drug delivery Uncouplers of oxidative phosphorylation
acetylcysteine antioxidant ascorbic acid berberine derivative cell penetrating peptide cyanine dye dequalinium elamipretide glutathione placebo pyridinium derivative quaternary ammonium derivative reactive oxygen metabolite rhodamine signal peptide skq 1 triphenylphosphonium ubidecarenone unclassified drug 10-(6'-plastoquinonyl)decyltriphenylphosphonium 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide antioxidant organophosphorus compound plastoquinone reactive oxygen metabolite ubiquinone aging Alzheimer disease amyotrophic lateral sclerosis antioxidant activity Article chronic hepatitis C chronic kidney failure chronic obstructive lung disease diastolic dysfunction disorders of mitochondrial functions drug structure drug targeting Duchenne muscular dystrophy fatigue heart failure human Huntington chorea hypertension hypogonadism inclusion body myositis keratoconjunctivitis sicca maximum plasma concentration metabolic syndrome X mit
Background: Targeting of drugs to the subcellular compartments represents one of the modern trends in molecular pharmacology. The approach for targeting mitochondria was developed nearly 50 years ago, but only in the last decade has it started to become widely used for delivering drugs. A number of pathologies are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory and metabolic conditions. Objective: This mini-review aims to highlight the role of mitochondria in pathophysiological conditions and diseases, to classify and summarize our knowledge about targeting mitochondria and to review the most important preclinical and clinical data relating to the antioxidant lipophilic cations MitoQ and SkQ1. Methods: This is a review of available information in the PubMed and Clinical Trials databases (US National Library of Medicine) with no limiting period. Results and Conclusion: Mitochondria play an important role in the pathogenesis of many disease