Micro-RNA in lung transplant recipients: The prospects of clinical application [МиКрО-рНК У реЦиПиеНтОВ леГКиХ: ПерСПеКтиВЫ КлиНичеСКОГО ПриМеНеНиЯ]
Великиy Д. А., Шарапченко С. О., Пашков И. В., Гичкун О. Е., Шевченко О. П.
Вестник трансплантологии и искусственных органов
Т. 21, Вып. 2, С. 138-144
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.15825/1995-1191-2019-2-138-144
Аннотация:
This review summarizes the current literature devoted to the analysis of diagnostic role of biomarkers in rejection of the transplanted lung. Numerous researches have focused on small non-coding RNAs (micro-RNA) that regulate gene expression and affect various cell functions. Variations in the concentration of different micro-RNA have been shown in some pathological processes, including rejection of solid organs. Probably, measuring the level of micro-RNA in lung transplant may have value in the assessment of risk of rejection and possibility of minimizing immunosuppressive therapy. The accumulation of clinical data on the correlation of profiles of various biomarkers with clinical and laboratory parameters in lung recipients will help in finding non-invasive methods for the diagnosis rejection and improving long-term results of transplantation. © 2019 Russian Transplant Society. All rights reserved.
Ключевые слова:
Lung transplantation; MicroRNA; Obliterative bronchiolitis syndrome; Rejection
Язык текста: Русский
ISSN: 2412-6160
Великиy Д. А.
Шарапченко С. О.
Пашков И. В.
Гичкун О. Е. Ольга Евгеньевна 1984-
Шевченко О. П. Ольга Павловна 1952-
Velikiy D. A.
Sharapchenko S. O.
Pashkov I. V.
Gichkun O. E. Ol`ga Evgenyevna 1984-
Shevchenko O. P. Ol`ga Pavlovna 1952-
Micro-RNA in lung transplant recipients: The prospects of clinical application [МиКрО-рНК У реЦиПиеНтОВ леГКиХ: ПерСПеКтиВЫ КлиНичеСКОГО ПриМеНеНиЯ]
Текст визуальный непосредственный
Вестник трансплантологии и искусственных органов
Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова
Т. 21, Вып. 2 С. 138-144
2019
Статья
Lung transplantation MicroRNA Obliterative bronchiolitis syndrome Rejection
This review summarizes the current literature devoted to the analysis of diagnostic role of biomarkers in rejection of the transplanted lung. Numerous researches have focused on small non-coding RNAs (micro-RNA) that regulate gene expression and affect various cell functions. Variations in the concentration of different micro-RNA have been shown in some pathological processes, including rejection of solid organs. Probably, measuring the level of micro-RNA in lung transplant may have value in the assessment of risk of rejection and possibility of minimizing immunosuppressive therapy. The accumulation of clinical data on the correlation of profiles of various biomarkers with clinical and laboratory parameters in lung recipients will help in finding non-invasive methods for the diagnosis rejection and improving long-term results of transplantation. © 2019 Russian Transplant Society. All rights reserved.