Аннотация:
Water solubility of prothionamide and its solid dispersions with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin was studied. The most promising results were obtained with the solid dispersion with polyvinylpyrrolidone, which provided a 2.6-fold general increase of drug’s solubility and about a 6-fold dissolution rate increase, the maximal values among the studied drug forms. The results of complex physicochemical studies suggested that the improved drug release was due to micronization and solubilizing action of the polymer. A principal factor was the destruction of the crystal lattice and formation of amorphous particles in the solid dispersion. The obtained data can be useful for the development of modified pharmaceutical forms of prothionamide with improved drug release profile. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
Polyethyleneglycol-1500 (PEG); Polyvinylpyrrolidone-10000 (PVP); Prothionamide; Solid dispersions; Solubility; β-Cyclodextrin
Controlled drug delivery; Cyclodextrins; Solubility; Targeted drug delivery; Amorphous particles; Beta-cyclodextrin; Dissolution rates; Physicochemical studies; Poly vinyl pyrrolidone; Prothionamide; Solid dispersion; Water solubilities; Dispersions; beta cyclodextrin derivative; macrogol; macrogol 1500; povidone; protionamide; unclassified drug; Article; bioavailability; crystal structure; dispersion; drug release; drug solubility; kinetics; microscopy; physical chemistry; solubilization; X ray analysis
Krasnyuk I. I. Ivan Ivanovich 1979-
Belyatskaya A. V. Anastasiya Vladimirovna 1982-
Krasnyuk I. I. Ivan Ivanovich 1955-
Stepanova O. I. Ol`ga Ivanovna 1988-
Galkina I. V.
Lutsenko S. V. Sergej Viktorovich 1957-
Litvinova T. M. Tat`yana Mikhaylovna 1962-
Краснюк И. И. Иван Иванович 1979-
Беляцкая А. В. Анастасия Владимировна 1982-
Краснюк И. И. Иван Иванович 1955-
Степанова О. И. Ольга Ивановна 1988-
Галкина И. В.
Луценко С. В. Сергей Викторович 1957-
Литвинова Т. М. Татьяна Михайловна 1962-
Novel Solid Dispersions Increasing the Solubility of Prothionamide
Текст визуальный непосредственный
BioNanoScience
Vol.9, Issue4 P. 833-838
2019
Статья
Polyethyleneglycol-1500 (PEG) Polyvinylpyrrolidone-10000 (PVP) Prothionamide Solid dispersions Solubility β-Cyclodextrin
Controlled drug delivery Cyclodextrins Solubility Targeted drug delivery Amorphous particles Beta-cyclodextrin Dissolution rates Physicochemical studies Poly vinyl pyrrolidone Prothionamide Solid dispersion Water solubilities Dispersions beta cyclodextrin derivative macrogol macrogol 1500 povidone protionamide unclassified drug Article bioavailability crystal structure dispersion drug release drug solubility kinetics microscopy physical chemistry solubilization X ray analysis
Water solubility of prothionamide and its solid dispersions with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin was studied. The most promising results were obtained with the solid dispersion with polyvinylpyrrolidone, which provided a 2.6-fold general increase of drug’s solubility and about a 6-fold dissolution rate increase, the maximal values among the studied drug forms. The results of complex physicochemical studies suggested that the improved drug release was due to micronization and solubilizing action of the polymer. A principal factor was the destruction of the crystal lattice and formation of amorphous particles in the solid dispersion. The obtained data can be useful for the development of modified pharmaceutical forms of prothionamide with improved drug release profile. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.