Physiologically based mathematical modelling of solute transport within the epidermis and dermis
Calcutt J. J., Anissimov Yu. G.
International Journal of Pharmaceutics
Vol.569, Num.118547
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.ijpharm.2019.118547
Аннотация:
The stratum corneum is the main barrier to transdermal drug delivery which has previously resulted in mathematical modelling of solute transport in the skin being primarily directed at this skin layer. However, for topical treatment and skin toxicity studies, the concentration in the epidermis and dermis is important and needs to be modelled mathematically. Hitherto, mathematical models for viable skin layers typically simplified the clearance of solute by blood, either assuming sink condition at the top of the skin capillary loops or assuming a distributed clearance in the dermis. This paper is an attempt to develop a physiologically based mathematical model of drug transport in the viable skin. It incorporates explicit modelling of the capillary loops within the dermis and employs COMSOL Multiphysics® software to model the transport in three dimensions. Previously derived simplified models were compared to the results from this new numerical model. The results of this comparison show
Ключевые слова:
Capillary clearance; COMSOL®; Dermal transport; Diffusion
Article; capillary; capillary wall; dermis; drug transport; epidermis; mathematical model; maximum concentration; priority journal; sensitivity analysis; skin; software; solute; stratum corneum; biological model; dermis; epidermis; metabolism; transport at the cellular level; Biological Transport; Dermis; Epidermis; Models, Biological
Язык текста: Английский
ISSN: 1873-3476
Calcutt J. J.
Anissimov Yu. G. Yurij German 1965-
Cалcутт Й. Й.
Аниссимов Ю. Г. Юрий Герман 1965-
Physiologically based mathematical modelling of solute transport within the epidermis and dermis
Текст визуальный непосредственный
International Journal of Pharmaceutics
Elsevier Science Publisher B.V.
Vol.569 Num.118547
2019
Статья
Capillary clearance COMSOL® Dermal transport Diffusion
Article capillary capillary wall dermis drug transport epidermis mathematical model maximum concentration priority journal sensitivity analysis skin software solute stratum corneum biological model dermis epidermis metabolism transport at the cellular level Biological Transport Dermis Epidermis Models, Biological
The stratum corneum is the main barrier to transdermal drug delivery which has previously resulted in mathematical modelling of solute transport in the skin being primarily directed at this skin layer. However, for topical treatment and skin toxicity studies, the concentration in the epidermis and dermis is important and needs to be modelled mathematically. Hitherto, mathematical models for viable skin layers typically simplified the clearance of solute by blood, either assuming sink condition at the top of the skin capillary loops or assuming a distributed clearance in the dermis. This paper is an attempt to develop a physiologically based mathematical model of drug transport in the viable skin. It incorporates explicit modelling of the capillary loops within the dermis and employs COMSOL Multiphysics® software to model the transport in three dimensions. Previously derived simplified models were compared to the results from this new numerical model. The results of this comparison show