The influence of taurine and L-carnitine on 6 β-hydroxycortisol/cortisol ratio in human urine of healthy volunteers
Makhova A. A., Shikh E. V., Bulko T. V., Sizova Zh. M., Shumyantseva V. V.
Drug Metabolism and Personalized Therapy
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1515/dmpt-2019-0013
Аннотация:
Background Cytochrome P450s (CYPs, EC 1.14.14.1) are the main enzymes of drug metabolism. The functional significance of CYPs also includes the metabolism of foreign chemicals and endogenic biologically active compounds. The CYP3A4 isoform contributes to the metabolism of about half of all marketed medicinal preparations. The aim of this study was to investigate the effects of two biologically active compounds: 2-aminoethane-sulfonic acid (taurine) and 3-hydroxy-4-trimethylaminobutyrate (L-carnitine) on urinary 6β-hydroxycortisol/cortisol (6β-OHC/cortisol) metabolic ratio as a biomarker of the CYP3A4 activity of healthy volunteers. Taurine is used for the treatment of chronic heart failure and liver disease. Cardiologists, nephrologists, neurologists, gerontologists in addition to the main etiopathogenetic therapies, use L-carnitine. The quantification of the 6β-OHC/cortisol metabolic ratio as a biomarker of CYP3A4 activity in human urine was used for the assessment of CYP3A4 catalytic
Ключевые слова:
6β-hydroxycortisol/cortisol metabolic ratio; cytochrome P450 3A4; L-carnitine; taurine; urine; volunteers
6 beta-hydroxycortisol; biological marker; carnitine; CYP3A4 protein, human; cytochrome P450 3A; hydrocortisone; taurine; adolescent; adult; human; liquid chromatography; male; mass spectrometry; metabolism; normal human; oral drug administration; urine; young adult; Administration, Oral; Adolescent; Adult; Biomarkers; Carnitine; Chromatography, Liquid; Cytochrome P-450 CYP3A; Healthy Volunteers; Humans; Hydrocortisone; Male; Mass Spectrometry; Taurine; Young Adult
Язык текста: Английский
ISSN: 2363-8915
Makhova A. A. Anna Aleksandrovna 1983-
Shikh E. V. Evgeniya Valeryevna 1962-
Bulko T. V.
Sizova Zh. M. Zhanna Mikhaylovna 1959-
Shumyantseva V. V.
Махова А. А. Анна Александровна 1983-
Ших Е. В. Евгения Валерьевна 1962-
Булко Т. В.
Сизова Ж. М. Жанна Михайловна 1959-
Шумянцева В. В.
The influence of taurine and L-carnitine on 6 β-hydroxycortisol/cortisol ratio in human urine of healthy volunteers
Текст визуальный непосредственный
Drug Metabolism and Personalized Therapy
Walter de Gruyter GmbH
Vol.34, Issue3
2019
Статья
6β-hydroxycortisol/cortisol metabolic ratio cytochrome P450 3A4 L-carnitine taurine urine volunteers
6 beta-hydroxycortisol biological marker carnitine CYP3A4 protein, human cytochrome P450 3A hydrocortisone taurine adolescent adult human liquid chromatography male mass spectrometry metabolism normal human oral drug administration urine young adult Administration, Oral Adolescent Adult Biomarkers Carnitine Chromatography, Liquid Cytochrome P-450 CYP3A Healthy Volunteers Humans Hydrocortisone Male Mass Spectrometry Taurine Young Adult
Background Cytochrome P450s (CYPs, EC 1.14.14.1) are the main enzymes of drug metabolism. The functional significance of CYPs also includes the metabolism of foreign chemicals and endogenic biologically active compounds. The CYP3A4 isoform contributes to the metabolism of about half of all marketed medicinal preparations. The aim of this study was to investigate the effects of two biologically active compounds: 2-aminoethane-sulfonic acid (taurine) and 3-hydroxy-4-trimethylaminobutyrate (L-carnitine) on urinary 6β-hydroxycortisol/cortisol (6β-OHC/cortisol) metabolic ratio as a biomarker of the CYP3A4 activity of healthy volunteers. Taurine is used for the treatment of chronic heart failure and liver disease. Cardiologists, nephrologists, neurologists, gerontologists in addition to the main etiopathogenetic therapies, use L-carnitine. The quantification of the 6β-OHC/cortisol metabolic ratio as a biomarker of CYP3A4 activity in human urine was used for the assessment of CYP3A4 catalytic