Relation of functional activity of platelets to prognosis of unfavorable cardiovascular events in patients with acute coronary syndrome. Results of...
Ломакин Н. В., Бурячковскайа Л. И., Сумароков А. Б., Габбасов З. А., Герасимов А. Н.
Кардиология
Т. 59, Вып. 10, С. 5-13
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.18087/cardio.2019.10.n678
Аннотация:
Aim: to assess relation of high functional activity of platelets to prognosis of unfavorable cardiovascular events in patients with Acute Coronary Syndrome (ACS). Materials. The study was based on the data of a single center ACS registry conducted in the Central Clinical Hospital of the Presidential Affairs Department of Russian Federation. Of 529 included patients in 425 without contraindications to double antiplatelet therapy we carried out analysis of dependence of 30 days level of unfavorable events on parameters of functional activity of platelets. Results. High on-treatment platelet reactivity (HTPR) was found to be associated with 3.5 increase of mortality in the group of patients with high cardiovascular risk. Logistic model of prognosis of unfavorable events based on multifactorial analysis of data from patients with measured platelet aggregation included chronic kidney disease, type of myocardial infarction, and degree of platelet aggregation >45[%]. C-statistic was equal to 0.
Ключевые слова:
ACS; Bleeding; Functional platelet activity; Prognosis; Real clinical practice; Thrombosis
antithrombocytic agent; clopidogrel; ticlopidine; acute coronary syndrome; human; prognosis; register; Russian Federation; thrombocyte; Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prognosis; Registries; Russia; Ticlopidine
Язык текста: Русский
ISSN: 0022-9040
Ломакин Н. В.
Бурячковскайа Л. И.
Сумароков А. Б.
Габбасов З. А.
Герасимов А. Н. Андрей Николаевич 1958-
Lomakin N. V.
Buryachkovskaya L. I.
Sumarokov A. B.
Gabbasov Z. A.
Gerasimov A. N. Andrej Nikolaevich 1958-
Relation of functional activity of platelets to prognosis of unfavorable cardiovascular events in patients with acute coronary syndrome. Results of a registry study [Взаимосвязь функциональной активности тромбоцитов с прогнозом неблагоприятных сердечно-сосудистых событий у больных острым коронарным синдромом. Результаты регистрового исследования]
Relation of functional activity of platelets to prognosis of unfavorable cardiovascular events in patients with acute coronary syndrome. Results of...
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Т. 59, Вып. 10 С. 5-13
2019
Статья
ACS Bleeding Functional platelet activity Prognosis Real clinical practice Thrombosis
antithrombocytic agent clopidogrel ticlopidine acute coronary syndrome human prognosis register Russian Federation thrombocyte Acute Coronary Syndrome Blood Platelets Clopidogrel Humans Platelet Aggregation Inhibitors Prognosis Registries Russia Ticlopidine
Aim: to assess relation of high functional activity of platelets to prognosis of unfavorable cardiovascular events in patients with Acute Coronary Syndrome (ACS). Materials. The study was based on the data of a single center ACS registry conducted in the Central Clinical Hospital of the Presidential Affairs Department of Russian Federation. Of 529 included patients in 425 without contraindications to double antiplatelet therapy we carried out analysis of dependence of 30 days level of unfavorable events on parameters of functional activity of platelets. Results. High on-treatment platelet reactivity (HTPR) was found to be associated with 3.5 increase of mortality in the group of patients with high cardiovascular risk. Logistic model of prognosis of unfavorable events based on multifactorial analysis of data from patients with measured platelet aggregation included chronic kidney disease, type of myocardial infarction, and degree of platelet aggregation >45[%]. C-statistic was equal to 0.