Аннотация:
Finding the best options for combined antihypertensive therapy is one of the main tasks to be solved for achieving target blood pressure (BP) and, accordingly, reduction of the risk of complications in patients with arterial hypertension (AH). Purpose of this study was to evaluate the effectiveness of the perindopril arginine/amlodipine fixed combination in patients with 1-2 degree hypertension not achieving BP control on previous therapy with sartan-containing free combinations. Materials and methods. In the multicenter open uncontrolled observational program AVANGARD 203 doctors in 53 cities of the Russian Federation included 658 patients who had not achieved target BP on therapy with two drugs, one of which was sartan (sartan with diuretic, calcium antagonist, β-blocker, or moxonidine in 49[%], 33[%], 17[%], and 1[%] of cases, respectively). This therapy was replaced with a fixed combination of perindopril arginine/amlodipine. Duration of observation was 3 months. Results. On therapy with p
Ключевые слова:
Arterial hypertension; Combination therapy; Perindopril/amlodipine
amlodipine; angiotensin 1 receptor antagonist; antihypertensive agent; perindopril; blood pressure; drug combination; human; hypertension; Russian Federation; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Drug Combinations; Humans; Hypertension; Perindopril; Russia
Глезер М. Г.
Glezer M. G.
Antihypertensive effect of switching to a fixed perindopril/amlodipine combination in patients ineffectively treated by free Sartan-containing combinations. Results of the Avangard study [Антигипертензивный эффект при переводе на фиксированную комбинацию периндоприл/амлодипин при неэффективности терапии свободными комбинациями, содержащими сартаны. Результаты исследования АВАНГАРД]
Antihypertensive effect of switching to a fixed perindopril/amlodipine combination in patients ineffectively treated by free Sartan-containing...
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Т. 59, Вып. 10 С. 31-38
2019
Статья
Arterial hypertension Combination therapy Perindopril/amlodipine
amlodipine angiotensin 1 receptor antagonist antihypertensive agent perindopril blood pressure drug combination human hypertension Russian Federation Amlodipine Angiotensin II Type 1 Receptor Blockers Antihypertensive Agents Blood Pressure Drug Combinations Humans Hypertension Perindopril Russia
Finding the best options for combined antihypertensive therapy is one of the main tasks to be solved for achieving target blood pressure (BP) and, accordingly, reduction of the risk of complications in patients with arterial hypertension (AH). Purpose of this study was to evaluate the effectiveness of the perindopril arginine/amlodipine fixed combination in patients with 1-2 degree hypertension not achieving BP control on previous therapy with sartan-containing free combinations. Materials and methods. In the multicenter open uncontrolled observational program AVANGARD 203 doctors in 53 cities of the Russian Federation included 658 patients who had not achieved target BP on therapy with two drugs, one of which was sartan (sartan with diuretic, calcium antagonist, β-blocker, or moxonidine in 49[%], 33[%], 17[%], and 1[%] of cases, respectively). This therapy was replaced with a fixed combination of perindopril arginine/amlodipine. Duration of observation was 3 months. Results. On therapy with p