Association of Hyponatremia With Survival in Patients With Castration-resistant Prostate Cancer: A Clinical Commentary
Stangl-Kremser J., Kramer G., Shariat Sh.
Clinical genitourinary cancer.
Vol.17, Issue6, P. e1188-e1192
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.clgc.2019.08.001
Аннотация:
Hyponatremia has been associated with an increased risk of demise in several malignancies. The aim of the current study was to evaluate its prognostic value in patients with castration-resistant prostate cancer. In 186 patients planned for docetaxel chemotherapy, we detected an association between hyponatremia and decreased survival (P = .04). We suggest conducting further well-designed studies including full workup of hyponatremia. © 2019 Elsevier Inc.Introduction: The aim of this study was to evaluate the prognostic value of hyponatremia in patients with castration-resistant prostate cancer (CRPC) undergoing docetaxel chemotherapy. Patients and Methods: We retrospectively assessed 186 patients who received docetaxel chemotherapy in addition to androgen deprivation for CRPC between 2005 and 2015. We stratified the patients according to their pre-chemotherapy serum sodium level. Hyponatremia was defined as sodium < 135 mmol/L. A Cox proportional regression model was used to estimate ov
Ключевые слова:
Hyponatremia; Prognostic; Prostate cancer; Survival
docetaxel; prednisolone; sodium; antineoplastic agent; docetaxel; sodium; adult; aged; Article; cancer survival; castration resistant prostate cancer; controlled study; follow up; human; hyponatremia; major clinical study; male; overall survival; retrospective study; sodium blood level; blood; castration resistant prostate cancer; hyponatremia; Kaplan Meier method; middle aged; mortality; prognosis; proportional hazards model; treatment outcome; Aged; Antineoplastic Agents; Docetaxel; Follow-Up Studies; Humans; Hyponatremia; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Proportional Hazards Models; Prostatic Neoplasms, Castration-Resistant; Retrospective Studies; Sodium; Treatment Outcome
Язык текста: Английский
ISSN: 1938-0682
Stangl-Kremser J.
Kramer G.
Shariat Sh. Sharokh 1973-
Стангл-Кремсер Й.
Крамер Г.
Шариат Ш. Шарох 1973-
Association of Hyponatremia With Survival in Patients With Castration-resistant Prostate Cancer: A Clinical Commentary
Текст визуальный непосредственный
Clinical genitourinary cancer.
Cancer Information Group
Vol.17, Issue6 P. e1188-e1192
2019
Статья
Hyponatremia Prognostic Prostate cancer Survival
docetaxel prednisolone sodium antineoplastic agent docetaxel sodium adult aged Article cancer survival castration resistant prostate cancer controlled study follow up human hyponatremia major clinical study male overall survival retrospective study sodium blood level blood castration resistant prostate cancer hyponatremia Kaplan Meier method middle aged mortality prognosis proportional hazards model treatment outcome Aged Antineoplastic Agents Docetaxel Follow-Up Studies Humans Hyponatremia Kaplan-Meier Estimate Male Middle Aged Prognosis Proportional Hazards Models Prostatic Neoplasms, Castration-Resistant Retrospective Studies Sodium Treatment Outcome
Hyponatremia has been associated with an increased risk of demise in several malignancies. The aim of the current study was to evaluate its prognostic value in patients with castration-resistant prostate cancer. In 186 patients planned for docetaxel chemotherapy, we detected an association between hyponatremia and decreased survival (P = .04). We suggest conducting further well-designed studies including full workup of hyponatremia. © 2019 Elsevier Inc.Introduction: The aim of this study was to evaluate the prognostic value of hyponatremia in patients with castration-resistant prostate cancer (CRPC) undergoing docetaxel chemotherapy. Patients and Methods: We retrospectively assessed 186 patients who received docetaxel chemotherapy in addition to androgen deprivation for CRPC between 2005 and 2015. We stratified the patients according to their pre-chemotherapy serum sodium level. Hyponatremia was defined as sodium < 135 mmol/L. A Cox proportional regression model was used to estimate ov