Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin
Smigic J., Sabo T., Vranic A., Zivkovic V., Srejovic I., Turnic T. N., Milosavljevic I., Poljarevic J., Krivokapic M., Bolevich S., Yakovlevich V.
Molecular and Cellular Biochemistry
Vol.458, Issue1-2, P. 89-98
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s11010-019-03533-8
Аннотация:
The aim of the present study was to compare the cardiodynamic parameters in the isolated rat heart in animals chronically treated with cisplatin, platinum(IV) complex and its diamine ligand. Sixty Wistar albino rats (8 weeks old) were divided into five groups: three experimental and two control groups. Animals in all groups were treated with a dose of 4 mg/kg body weight once a week for 4 weeks with different substances; experimental groups received cisplatin, ligand and octahedral platinum(IV) complex, and control groups received saline and dimethyl sulfoxide. After sacrificing the animals, hearts were isolated and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40–120 cmH2O). The following parameters of cardiac function were continuously recorded: maximum and minimum rate of change of pressure in the left ventricle, systolic and diastolic left ventricular pressure, heart rate and coronary flow. The results showed statistically sign
Ключевые слова:
Cardiodynamics; Cisplatin; Ligand; Platinum(IV) complex; Rat
antineoplastic metal complex; cisplatin; diamine derivative; o,o' diethyl(s,s ethylenediamine n,n' di 2 (3cyclohexyl)propanoate; unclassified drug; cisplatin; diamine; animal experiment; animal model; animal tissue; Article; cardiotoxicity; chronic drug administration; comparative study; controlled study; coronary artery blood flow; diastolic blood pressure; heart function; heart left ventricle pressure; heart muscle contractility; heart rate; isolated heart; long term care; male; nonhuman; rat; systolic blood pressure; Wistar rat; animal; blood pressure; drug effect; heart left ventricle function; Animals; Blood Pressure; Cisplatin; Coronary Circulation; Diamines; Heart Rate; Male; Rats; Rats, Wistar; Ventricular Function, Left
Язык текста: Английский
ISSN: 1573-4919
Smigic J.
Sabo T.
Vranic A.
Zivkovic V.
Srejovic I.
Turnic T. N.
Milosavljevic I.
Poljarevic J.
Krivokapic M.
Bolevich S. Sergej 1964-
Yakovlevich V. Vladimir 1971-
Смигиc Й.
Сабо Т.
Враниc А.
Зивковиc В.
Срейовиc И.
Тюрниc Т. Н.
Милосавлйевиc И.
Полйаревиc Й.
Кривокапиc М.
Болевич С. Сергей 1964-
Яковлевич В. Владимир 1971-
Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin
Текст визуальный непосредственный
Molecular and Cellular Biochemistry
Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
Vol.458, Issue1-2 P. 89-98
2019
Статья
Cardiodynamics Cisplatin Ligand Platinum(IV) complex Rat
antineoplastic metal complex cisplatin diamine derivative o,o' diethyl(s,s ethylenediamine n,n' di 2 (3cyclohexyl)propanoate unclassified drug cisplatin diamine animal experiment animal model animal tissue Article cardiotoxicity chronic drug administration comparative study controlled study coronary artery blood flow diastolic blood pressure heart function heart left ventricle pressure heart muscle contractility heart rate isolated heart long term care male nonhuman rat systolic blood pressure Wistar rat animal blood pressure drug effect heart left ventricle function Animals Blood Pressure Cisplatin Coronary Circulation Diamines Heart Rate Male Rats Rats, Wistar Ventricular Function, Left
The aim of the present study was to compare the cardiodynamic parameters in the isolated rat heart in animals chronically treated with cisplatin, platinum(IV) complex and its diamine ligand. Sixty Wistar albino rats (8 weeks old) were divided into five groups: three experimental and two control groups. Animals in all groups were treated with a dose of 4 mg/kg body weight once a week for 4 weeks with different substances; experimental groups received cisplatin, ligand and octahedral platinum(IV) complex, and control groups received saline and dimethyl sulfoxide. After sacrificing the animals, hearts were isolated and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40–120 cmH2O). The following parameters of cardiac function were continuously recorded: maximum and minimum rate of change of pressure in the left ventricle, systolic and diastolic left ventricular pressure, heart rate and coronary flow. The results showed statistically sign