Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice
Blinova E. V., Dudina M. O., Suslova I. R., Samishina E. A., Blinov D. S., Roshchin D. A.
Journal of Advanced Pharmaceutical Technology and Research
Vol.9, Issue4, P. 130-134
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.4103/japtr.JAPTR_313_18
Аннотация:
2-Amino-4H-chromene derivatives possess anticancer property proved on different in vivo and in vitro models of malignancies such breast, nasopharyngeal, bladder, ovary carcinomas, astrocytoma, and osteosarcoma. We assumed it might be effective to apply one of the derivatives as promising approach to lung carcinoma treatment.To evaluate how novel 4-Aryl substituted 2-Amino-4H-chromene derivative AX-554 impacts tumor growth and progression, as well as possible mechanisms for anticancer effect development on in vivo patient-derived heterotopic xenograft model of lung carcinoma in mice. This was an experimental in vivo study. 40 nu/nu BALB/c female mice were randomly allocated into four equal groups: Intact, control, reference, and main group. Animals of three latter groups were ingrafted with human-derived lung adenocarcinoma. Antitumor and antimetastatic action of AX-554 novel aminochromone derivative as a substance were studied. Mice survival was registered. Kinase of anaplastic lymphom
Ключевые слова:
Aminochromone derivative; apoptosis; lung cancer; receptor tyrosine kinases; tubulin
aminochromone derivative; anaplastic lymphoma kinase; antineoplastic agent; ax 554; beta tubulin; cyclophosphamide; scatter factor receptor; tubulin beta 3; unclassified drug; animal experiment; animal model; animal tissue; apoptosis; Article; cancer inhibition; cell proliferation; controlled study; drug effect; enzyme linked immunosorbent assay; epithelial mesenchymal transition; female; homogenate; in vivo study; life expectancy; lung carcinoma; metastasis inhibition; mouse; nonhuman; priority journal; quantitative analysis; substitution reaction; survival rate; tumor xenograft
Язык текста: Английский
ISSN: 0976-2094
Blinova E. V. Ekaterina Valerievna 1981-
Dudina M. O.
Suslova I. R. Irina Rudol`fovna 1972-
Samishina E. A.
Blinov D. S.
Roshchin D. A.
Блинова Е. В. Екатерина Валериевна 1981-
Дудина М. О.
Суслова И. Р. Ирина Рудольфовна 1972-
Самишина Е. А.
Блинов Д. С.
Рошчин Д. А.
Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice
Текст визуальный непосредственный
Journal of Advanced Pharmaceutical Technology and Research
Vol.9, Issue4 P. 130-134
2018
Статья
Aminochromone derivative apoptosis lung cancer receptor tyrosine kinases tubulin
aminochromone derivative anaplastic lymphoma kinase antineoplastic agent ax 554 beta tubulin cyclophosphamide scatter factor receptor tubulin beta 3 unclassified drug animal experiment animal model animal tissue apoptosis Article cancer inhibition cell proliferation controlled study drug effect enzyme linked immunosorbent assay epithelial mesenchymal transition female homogenate in vivo study life expectancy lung carcinoma metastasis inhibition mouse nonhuman priority journal quantitative analysis substitution reaction survival rate tumor xenograft
2-Amino-4H-chromene derivatives possess anticancer property proved on different in vivo and in vitro models of malignancies such breast, nasopharyngeal, bladder, ovary carcinomas, astrocytoma, and osteosarcoma. We assumed it might be effective to apply one of the derivatives as promising approach to lung carcinoma treatment.To evaluate how novel 4-Aryl substituted 2-Amino-4H-chromene derivative AX-554 impacts tumor growth and progression, as well as possible mechanisms for anticancer effect development on in vivo patient-derived heterotopic xenograft model of lung carcinoma in mice. This was an experimental in vivo study. 40 nu/nu BALB/c female mice were randomly allocated into four equal groups: Intact, control, reference, and main group. Animals of three latter groups were ingrafted with human-derived lung adenocarcinoma. Antitumor and antimetastatic action of AX-554 novel aminochromone derivative as a substance were studied. Mice survival was registered. Kinase of anaplastic lymphom