Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology
Sennikov S. V., Alshevskaya A. A., Zhukova J., Belomestnova I., Karaulov A. V., Lopatnikova J. A.
International Archives of Allergy and Immunology
Vol.178, Issue2, P. 182-191
Опубликовано: 2019
Тип ресурса: Обзор
Аннотация:
The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator receptor expression for main classes of pathologies. For all major types of immune mediators (cytokines, interleukins, chemokines, growth factors, and tumor necrosis factors), it has been shown that change
Ключевые слова:
Cellular immunology; Cytokine expression; Cytokine receptors; Cytokines; Immune regulation
chemokine; cytokine; cytokine receptor; growth factor; interleukin derivative; regulator protein; tumor necrosis factor; biological marker; immunoglobulin receptor; allergy; autoimmunity; carcinogenesis; cell density; cell function; cellular immunity; human; immunoregulation; pathogenesis; priority journal; protein expression; protein function; Review; disease predisposition; gene expression regulation; genetics; immunomodulation; metabolism; Biomarkers; Disease Susceptibility; Gene Expression Regulation; Humans; Immunomodulation; Receptors, Immunologic
Язык текста: Английский
ISSN: 1423-0097
Sennikov S. V.
Alshevskaya A. A.
Zhukova J.
Belomestnova I.
Karaulov A. V. Aleksandr Viktorovich 1953-
Lopatnikova J. A.
Сенников С. В.
Алшевскайа А. А.
Жукова Й.
Беломестнова И.
Караулов А. В. Александр Викторович 1953-
Лопатникова Й. А.
Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology
Текст визуальный непосредственный
International Archives of Allergy and Immunology
S. Karger AG
Vol.178, Issue2 P. 182-191
2019
Обзор
Cellular immunology Cytokine expression Cytokine receptors Cytokines Immune regulation
chemokine cytokine cytokine receptor growth factor interleukin derivative regulator protein tumor necrosis factor biological marker immunoglobulin receptor allergy autoimmunity carcinogenesis cell density cell function cellular immunity human immunoregulation pathogenesis priority journal protein expression protein function Review disease predisposition gene expression regulation genetics immunomodulation metabolism Biomarkers Disease Susceptibility Gene Expression Regulation Humans Immunomodulation Receptors, Immunologic
The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator receptor expression for main classes of pathologies. For all major types of immune mediators (cytokines, interleukins, chemokines, growth factors, and tumor necrosis factors), it has been shown that change