Аннотация:
Aim. To perform a comparative analysis of anemia of chronic disease (ACD) and iron-deficiency anemia (IDA) in late middle-aged and elderly patients with chronic heart failure (CHF) by ferrokinetic parameters, inflammation indexes, and their associations. Materials and methods. 65 patients with ischemic heart disease were evaluated, including 35 patients with CHF and ACD, 10 patients with CHF and IDA, and 20 patients without CHF, ACD, and IDA (control group, CG). Results. Patients with CHF and IDA had true iron deficiency whereas 54[%] of patients with CHF and ACD had functional iron deficiency, and 46[%] of patients had no iron deficiency. Levels of acute phase proteins, ferritin and hepcidin, C-reactive protein (CRP), and interIeukin-6 (IL-6) were highly sig-nificantly different in patients with CHF and ACD and patients with CHF and IDA; positive and significant correlations were found for levels of IL-6 and ferritin, IL-6 and CRP, and CRP and hepcidin. In patients with CHF and IDA, level
Ключевые слова:
Anemia op chronic disease; Chronic heart failure; Erythropoietin; Ferritin; Hepcid1n; Interleukin-6 (il-6); Iron deficiency anemia
EPO protein, human; erythropoietin; ferritin; hepcidin; aged; anemia; chronic disease; comparative study; complication; female; heart failure; human; inflammation; iron deficiency anemia; male; metabolism; middle aged; Aged; Anemia; Anemia, Iron-Deficiency; Chronic Disease; Erythropoietin; Female; Ferritins; Heart Failure; Hepcidins; Humans; Inflammation; Male; Middle Aged
Соломахина Н. И. Нина Иосифовна 1954-
Находнова Е. С. Елена Сергеевна 1983-
Беленков Ю. Н. Юрий Никитич 1948-
Solomakhina N. I. Nina Iosifovna 1954-
Nakhodnova E. S. Elena Sergeevna 1983-
Belenkov Yu. N. Yurij Nikitich 1948-
Anemia of chronic disease and iron deficiency anemia: comparative characteristics of ferrokinetic parameters and their relationship with inflammation in late middle-aged and elderly patients with chf
Anemia of chronic disease and iron deficiency anemia: comparative characteristics of ferrokinetic parameters and their relationship with...
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Т. 58 С. 58-64
2018
Статья
Anemia op chronic disease Chronic heart failure Erythropoietin Ferritin Hepcid1n Interleukin-6 (il-6) Iron deficiency anemia
EPO protein, human erythropoietin ferritin hepcidin aged anemia chronic disease comparative study complication female heart failure human inflammation iron deficiency anemia male metabolism middle aged Aged Anemia Anemia, Iron-Deficiency Chronic Disease Erythropoietin Female Ferritins Heart Failure Hepcidins Humans Inflammation Male Middle Aged
Aim. To perform a comparative analysis of anemia of chronic disease (ACD) and iron-deficiency anemia (IDA) in late middle-aged and elderly patients with chronic heart failure (CHF) by ferrokinetic parameters, inflammation indexes, and their associations. Materials and methods. 65 patients with ischemic heart disease were evaluated, including 35 patients with CHF and ACD, 10 patients with CHF and IDA, and 20 patients without CHF, ACD, and IDA (control group, CG). Results. Patients with CHF and IDA had true iron deficiency whereas 54[%] of patients with CHF and ACD had functional iron deficiency, and 46[%] of patients had no iron deficiency. Levels of acute phase proteins, ferritin and hepcidin, C-reactive protein (CRP), and interIeukin-6 (IL-6) were highly sig-nificantly different in patients with CHF and ACD and patients with CHF and IDA; positive and significant correlations were found for levels of IL-6 and ferritin, IL-6 and CRP, and CRP and hepcidin. In patients with CHF and IDA, level