Standardized aronia melanocarpa extract as novel supplement against metabolic syndrome: A rat model
Jakoviljevic V., Milic P., Bradic J., Jeremic J., Zivkovic V., Srejovic I., Turnic T. N., Milosavljevic I., Jeremic N., Bolevich S., Borovic M. L., Mitrovic M., Vucic V.
International Journal of Molecular Sciences
Vol.20, Issue1, Num.6
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathol
Ключевые слова:
Aronia melanocarpa; Dietary strategies; Metabolic syndrome; Standardized extract; Supplementation
aronia melanocarpa extract; catalase; glucose; glutathione; hydrogen peroxide; insulin; iron; nitrite; plant extract; superoxide dismutase; unclassified drug; glucose; insulin; plant extract; animal experiment; animal model; antihypertensive activity; Aronia melanocarpa; Article; blood flowmetry; body mass; clinical protocol; comparative study; controlled study; coronary artery blood flow; diastolic blood pressure; diet supplementation; enzyme linked immunosorbent assay; ex vivo study; glucose tolerance; heart function; heart protection; heart rate; heart ventricle enddiastolic pressure; heart ventricle hypertrophy; heart ventricle size; histology; in vivo study; isolated heart; lipid diet; liver disease; liver structure; metabolic syndrome X; nonhuman; oral glucose tolerance test; oxidative stress; randomized controlled trial; rat; steatosis; systolic blood pressure; animal; animal food; blood pressure; chemistry; dietary supplement; disease model; glucose tolerance test; heart functi
Язык текста: Английский
ISSN: 1661-6596
Jakoviljevic V.
Milic P.
Bradic J.
Jeremic J.
Zivkovic V.
Srejovic I.
Turnic T. N.
Milosavljevic I.
Jeremic N.
Bolevich S. Sergej 1964-
Borovic M. L.
Mitrovic M.
Vucic V.
Йаковилйевиc В.
Милиc П.
Брадиc Й.
Йеремиc Й.
Зивковиc В.
Срейовиc И.
Тюрниc Т. Н.
Милосавлйевиc И.
Йеремиc Н.
Болевич С. Сергей 1964-
Боровиc М. Л.
Митровиc М.
Вуcиc В.
Standardized aronia melanocarpa extract as novel supplement against metabolic syndrome: A rat model
Текст визуальный непосредственный
International Journal of Molecular Sciences
Vol.20, Issue1 Num.6
2019
Статья
Aronia melanocarpa Dietary strategies Metabolic syndrome Standardized extract Supplementation
aronia melanocarpa extract catalase glucose glutathione hydrogen peroxide insulin iron nitrite plant extract superoxide dismutase unclassified drug glucose insulin plant extract animal experiment animal model antihypertensive activity Aronia melanocarpa Article blood flowmetry body mass clinical protocol comparative study controlled study coronary artery blood flow diastolic blood pressure diet supplementation enzyme linked immunosorbent assay ex vivo study glucose tolerance heart function heart protection heart rate heart ventricle enddiastolic pressure heart ventricle hypertrophy heart ventricle size histology in vivo study isolated heart lipid diet liver disease liver structure metabolic syndrome X nonhuman oral glucose tolerance test oxidative stress randomized controlled trial rat steatosis systolic blood pressure animal animal food blood pressure chemistry dietary supplement disease model glucose tolerance test heart functi
The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathol