Numerical Investigation of Analytical Models of Drug Flux Through Microporated Skin
Pavlov A. M., Rzhevskij A. S., Anissimov Yu. G.
Journal of Pharmaceutical Sciences
Vol.108, Issue1, P. 358-363
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.xphs.2018.11.009
Аннотация:
In this study, drug flux through microporated skin was modeled using detailed numerical solution of the diffusion equation. The results of the modeling were compared to previously published simplified and easy to use analytical equations. Limitations and accuracy of these equations were investigated. Appropriate modifications of the equations were identified to expand them to wider practical applications when pore shape is not circular. Numerical simulations have shown a good accuracy of the new simple equations when these are used within their limits of application. © 2019 American Pharmacists Association®
Ключевые слова:
diffusion process; flux prediction; microporation; numerical simulation; transdermal drug delivery
accuracy; Article; cutaneous parameters; drug transport; mathematical computing; mathematical model; microporated skin; minimally invasive procedure; non invasive procedure; pore density variation; pore radius variation; prediction; skin; animal; biological model; chemistry; cutaneous drug administration; diffusion; drug delivery system; in vitro study; metabolism; permeability; physiology; porosity; skin; skin absorption; drug; Administration, Cutaneous; Animals; Diffusion; Drug Delivery Systems; In Vitro Techniques; Models, Biological; Permeability; Pharmaceutical Preparations; Porosity; Skin; Skin Absorption
Язык текста: Английский
ISSN: 1520-6017
Pavlov A. M.
Rzhevskij A. S. Aleksej Sergeevich 1991-
Anissimov Yu. G. Yurij German 1965-
Павлов А. М.
Ржевский А. С. Алексей Сергеевич 1991-
Аниссимов Ю. Г. Юрий Герман 1965-
Numerical Investigation of Analytical Models of Drug Flux Through Microporated Skin
Текст визуальный непосредственный
Journal of Pharmaceutical Sciences
John Wiley & Sons
Vol.108, Issue1 P. 358-363
2019
Статья
diffusion process flux prediction microporation numerical simulation transdermal drug delivery
accuracy Article cutaneous parameters drug transport mathematical computing mathematical model microporated skin minimally invasive procedure non invasive procedure pore density variation pore radius variation prediction skin animal biological model chemistry cutaneous drug administration diffusion drug delivery system in vitro study metabolism permeability physiology porosity skin skin absorption drug Administration, Cutaneous Animals Diffusion Drug Delivery Systems In Vitro Techniques Models, Biological Permeability Pharmaceutical Preparations Porosity Skin Skin Absorption
In this study, drug flux through microporated skin was modeled using detailed numerical solution of the diffusion equation. The results of the modeling were compared to previously published simplified and easy to use analytical equations. Limitations and accuracy of these equations were investigated. Appropriate modifications of the equations were identified to expand them to wider practical applications when pore shape is not circular. Numerical simulations have shown a good accuracy of the new simple equations when these are used within their limits of application. © 2019 American Pharmacists Association®