Typical and atypical antipsychotics: How significant are the differences?
Сиволап Y. П.
Журнал неврологии и психиатрии им. C.C. Корсакова
Т. 118, Вып. 11, С. 125-129
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.17116/jnevro2018118111125
Аннотация:
A number of frequently discussed issues of clinical psychiatry include comparing the advantages and disadvantages of typical and atypical antipsychotics. It is believed that atypical antipsychotics are less likely to cause extrapyramidal disorders and have a more significant effect on the negative symptoms of schizophrenia compared to typical drugs. However, many randomized controlled and cohort studies, as well as systematic reviews and meta-analyses carried out on their basis, allow questioning the superiority of second-generation antipsychotics over their predecessors, in particular in terms of tolerability. Current scientific evidence provides sufficient evidence for the clinical use of chlorpromazine and other traditional antipsychotics, along with more recent medicines. © 2018, Media Sphera Publishing Group. All rights reserved.
Ключевые слова:
Atypical antipsychotics; Chlorpromazine; Clozapine; Extrapyramidal symptoms; Haloperidol; Negative symptoms; Positive symptoms; Schizophrenia; Schizophrenialike psychosis; Typical antipsychotics
atypical antipsychotic agent; chlorpromazine; neuroleptic agent; Article; comparative study; drug tolerability; extrapyramidal syndrome; human; meta analysis (topic); questionnaire; randomized controlled trial (topic); schizophrenia; systematic review (topic); schizophrenia; Antipsychotic Agents; Humans; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Schizophrenia; Systematic Reviews as Topic
Язык текста: Русский
ISSN: 2309-4729
Сиволап Y. П.
Sivolap Y. P.
Typical and atypical antipsychotics: How significant are the differences?
Текст визуальный непосредственный
Журнал неврологии и психиатрии им. C.C. Корсакова
Издательство Медиа Сфера
Т. 118, Вып. 11 С. 125-129
2018
Статья
Atypical antipsychotics Chlorpromazine Clozapine Extrapyramidal symptoms Haloperidol Negative symptoms Positive symptoms Schizophrenia Schizophrenialike psychosis Typical antipsychotics
atypical antipsychotic agent chlorpromazine neuroleptic agent Article comparative study drug tolerability extrapyramidal syndrome human meta analysis (topic) questionnaire randomized controlled trial (topic) schizophrenia systematic review (topic) schizophrenia Antipsychotic Agents Humans Meta-Analysis as Topic Randomized Controlled Trials as Topic Schizophrenia Systematic Reviews as Topic
A number of frequently discussed issues of clinical psychiatry include comparing the advantages and disadvantages of typical and atypical antipsychotics. It is believed that atypical antipsychotics are less likely to cause extrapyramidal disorders and have a more significant effect on the negative symptoms of schizophrenia compared to typical drugs. However, many randomized controlled and cohort studies, as well as systematic reviews and meta-analyses carried out on their basis, allow questioning the superiority of second-generation antipsychotics over their predecessors, in particular in terms of tolerability. Current scientific evidence provides sufficient evidence for the clinical use of chlorpromazine and other traditional antipsychotics, along with more recent medicines. © 2018, Media Sphera Publishing Group. All rights reserved.