Research article: Soluble HLA-i and HLA-ii molecules are potential prognostic markers of progression of systemic and local inflammation in patients...
Kubysheva N., Soodaeva S. K., Novikov V., Eliseeva T., Li T., Klimanov I., Kuzmina E., Baez-Medina H., Solovyev V., Ovsyannikov D. Y., Batyrshin I.
Disease Markers
Vol.2018, Num.3614341
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Soluble molecules of the major histocompatibility complex play an important role in the development of various immune-mediated diseases. However, there is not much information on the participation of these proteins in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of our work was to determine the content of soluble molecules of the major histocompatibility complex of classes I and II (sHLA-I and sHLA-II) in the exhaled breath condensate (EBC) and in the blood serum in patients with moderate to severe COPD during the exacerbation and stable phase. We investigated 105 patients (male) with COPD aged 46-67 and 21 healthy nonsmoking volunteers (male) comparable in age. The content of sHLA-I and sHLA-II molecules was studied using ELISA. We found an increase in the level of sHLA-I and sHLA-II molecules in EBC, as well as an enhancement in the serum content of sHLA-II in all the examined COPD patients compared to healthy nonsmoking volunteers. The revealed negative
Ключевые слова:
HLA antigen class 1; HLA antigen class 2; biological marker; HLA antigen class 1; HLA antigen class 2; adult; aged; Article; chronic obstructive lung disease; disease severity; enzyme linked immunosorbent assay; female; forced expiratory volume; forced vital capacity; human; human cell; inflammation; informed consent; lung function; major clinical study; male; respiratory tract parameters; systemic disease; volunteer; blood; breath analysis; case control study; chronic obstructive lung disease; inflammation; middle aged; normal human; pathophysiology; procedures; solubility; Adult; Biomarkers; Breath Tests; Case-Control Studies; Forced Expiratory Volume; Healthy Volunteers; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Humans; Inflammation; Middle Aged; Pulmonary Disease, Chronic Obstructive; Solubility
Язык текста: Английский
ISSN: 1875-8630
Kubysheva N.
Soodaeva S. K. Svetlana Keldibekovna 1955-
Novikov V.
Eliseeva T.
Li T.
Klimanov I.
Kuzmina E.
Baez-Medina H.
Solovyev V.
Ovsyannikov D. Y.
Batyrshin I.
Кубyшева Н.
Соодаева С. К. Светлана Келдибековна 1955-
Новиков В.
Елисеева Т.
Ли Т.
Климанов И.
Кузмина Е.
Баез-Медина Х.
Соловьев В.
Овсянников Д. Y.
Батyршин И.
Research article: Soluble HLA-i and HLA-ii molecules are potential prognostic markers of progression of systemic and local inflammation in patients with copd
Research article: Soluble HLA-i and HLA-ii molecules are potential prognostic markers of progression of systemic and local inflammation in patients...
Текст визуальный непосредственный
Disease Markers
I O S press
Vol.2018 Num.3614341
2018
Статья
HLA antigen class 1 HLA antigen class 2 biological marker HLA antigen class 1 HLA antigen class 2 adult aged Article chronic obstructive lung disease disease severity enzyme linked immunosorbent assay female forced expiratory volume forced vital capacity human human cell inflammation informed consent lung function major clinical study male respiratory tract parameters systemic disease volunteer blood breath analysis case control study chronic obstructive lung disease inflammation middle aged normal human pathophysiology procedures solubility Adult Biomarkers Breath Tests Case-Control Studies Forced Expiratory Volume Healthy Volunteers Histocompatibility Antigens Class I Histocompatibility Antigens Class II Humans Inflammation Middle Aged Pulmonary Disease, Chronic Obstructive Solubility
Soluble molecules of the major histocompatibility complex play an important role in the development of various immune-mediated diseases. However, there is not much information on the participation of these proteins in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of our work was to determine the content of soluble molecules of the major histocompatibility complex of classes I and II (sHLA-I and sHLA-II) in the exhaled breath condensate (EBC) and in the blood serum in patients with moderate to severe COPD during the exacerbation and stable phase. We investigated 105 patients (male) with COPD aged 46-67 and 21 healthy nonsmoking volunteers (male) comparable in age. The content of sHLA-I and sHLA-II molecules was studied using ELISA. We found an increase in the level of sHLA-I and sHLA-II molecules in EBC, as well as an enhancement in the serum content of sHLA-II in all the examined COPD patients compared to healthy nonsmoking volunteers. The revealed negative