Comparison of results obtained by elisa and neutralization test in assessing the protection of population from tick-borne encephalitis
Чемохаева Л. Л., Маикова Г. Б., Рогова Y. В., Романенко В. В., Анкудинова А. В., Килячина А. С., Воровлч М. Ф., Карганова Г. Г.
Вопросы вирусологии
Т. 63, Вып. 1, С. 36-40
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.18821/0507-4088-2018-63-1-36-40
Аннотация:
The enzyme-linked immunosorbent assay (ELISA) and the neutralization test (NT) are often used to determine the level of seropositive population and to evaluate the immunogenicity of vaccines. ELISA provides information on the total pool of antiviral antibodies, while NT allows the antiviral protection level of a person to be estimated. It is assumed that the 1: 100 titer in ELISA and the 1: 10 titer in NT are protective. Obviously, the ratio of the total pool and virus neutralizing antibodies can vary as a result of natural immunization or vaccination. In this study, two methods were used to study the blood serum samples taken in a group of inhabitants of the Sverdlovsk region aged from 1 to 60 years. The samples were collected before immunization and 30 days after two immunizations with inactivated vaccines against tick-borne encephalitis of different manufacturers. Immunizations were performed either according to a standard scheme (30-day interval between immunizations), or according
Ключевые слова:
ELISA; Level ofseropositive population; Neutralization test; Post-vaccination immune response; Tick-borne encephalitis virus; Vaccine against tick-borne encephalitis
Язык текста: Русский
ISSN: 2411-2097
Чемохаева Л. Л.
Маикова Г. Б.
Рогова Y. В. Ю.В.
Романенко В. В.
Анкудинова А. В.
Килячина А. С.
Воровлч М. Ф.
Карганова Г. Г. Галина Григорьевна 1956-
Chemokhaeva L. L.
Maikova G. B.
Rogova Y. V. Yu.V.
Romanenko V. V.
Ankudinova A. V.
Kilyachina A. S.
Vorovlch M. F.
Karganova G. G. Galina Grigoryevna 1956-
Comparison of results obtained by elisa and neutralization test in assessing the protection of population from tick-borne encephalitis
Текст визуальный непосредственный
Вопросы вирусологии
Издательство "Медицина"
Т. 63, Вып. 1 С. 36-40
2018
Статья
ELISA Level ofseropositive population Neutralization test Post-vaccination immune response Tick-borne encephalitis virus Vaccine against tick-borne encephalitis
The enzyme-linked immunosorbent assay (ELISA) and the neutralization test (NT) are often used to determine the level of seropositive population and to evaluate the immunogenicity of vaccines. ELISA provides information on the total pool of antiviral antibodies, while NT allows the antiviral protection level of a person to be estimated. It is assumed that the 1: 100 titer in ELISA and the 1: 10 titer in NT are protective. Obviously, the ratio of the total pool and virus neutralizing antibodies can vary as a result of natural immunization or vaccination. In this study, two methods were used to study the blood serum samples taken in a group of inhabitants of the Sverdlovsk region aged from 1 to 60 years. The samples were collected before immunization and 30 days after two immunizations with inactivated vaccines against tick-borne encephalitis of different manufacturers. Immunizations were performed either according to a standard scheme (30-day interval between immunizations), or according