Regenerative potential of biodegradable collagen matrix for healing full-thickness defect of conjunctiva in rabbits
Демура Т. А., Фисенко Н. В., Мамиконян В. Р., Коган Е. А., Аветисов С. Э.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 7, С. 34-38
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.30906/0869-2092-2018-81-7-34-38
Аннотация:
The regenerative potential of biodegradable collagen matrix (hemostatic sponge) for healing full-thickness rabbit conjunctival injury was studied. Results of histological investigation and scanning electron microscopy showed evidence of the progressive degradation of collagen matrix followed by granulation tissue formation from periphery to the center of the conjunctival wound. The ungrafted conjunctival defect was substituted with granulation tissue from the intact edges of wound to the center. Both matrix-grafted and ungrafted full-thickness conjunctival defects were covered completely with loose stroma and stratified squamous epithelium within 30 days. Thus, high regenerative potential of biodegradable collagen matrix (hemostatic sponge) implanted into the zone of injury for healing full-thickness defect of rabbit conjunctiva was established. © 2018 American Leather Chemists Association. All rights reserved.
Ключевые слова:
Collagen; Conjunctival wound; Regenerative potential; Scanning electron microscopy; Tissue repair; Wound healing
biomaterial; collagen sponge; animal experiment; animal model; animal tissue; Article; conjunctiva disease; experimental rabbit; extracellular matrix; granulation tissue; histology; nonhuman; protein degradation; scanning electron microscopy; squamous epithelium; stroma; tissue regeneration; treatment outcome; wound healing
Язык текста: Русский
ISSN: 0869-2092
Демура Т. А. Татьяна Александровна 1983-
Фисенко Н. В.
Мамиконян В. Р.
Коган Е. А. Евгения Алтаровна 1951-
Аветисов С. Э. Сергей Эдуардович 1950-
Demura T. A. Tat`yana Aleksandrovna 1983-
Fisenko N. V.
Mamikonyan V. R.
Kogan E. A. Evgeniya Altarovna 1951-
Avetisov S. E`. Sergej E`duardovich 1950-
Regenerative potential of biodegradable collagen matrix for healing full-thickness defect of conjunctiva in rabbits
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 7 С. 34-38
2018
Статья
Collagen Conjunctival wound Regenerative potential Scanning electron microscopy Tissue repair Wound healing
biomaterial collagen sponge animal experiment animal model animal tissue Article conjunctiva disease experimental rabbit extracellular matrix granulation tissue histology nonhuman protein degradation scanning electron microscopy squamous epithelium stroma tissue regeneration treatment outcome wound healing
The regenerative potential of biodegradable collagen matrix (hemostatic sponge) for healing full-thickness rabbit conjunctival injury was studied. Results of histological investigation and scanning electron microscopy showed evidence of the progressive degradation of collagen matrix followed by granulation tissue formation from periphery to the center of the conjunctival wound. The ungrafted conjunctival defect was substituted with granulation tissue from the intact edges of wound to the center. Both matrix-grafted and ungrafted full-thickness conjunctival defects were covered completely with loose stroma and stratified squamous epithelium within 30 days. Thus, high regenerative potential of biodegradable collagen matrix (hemostatic sponge) implanted into the zone of injury for healing full-thickness defect of rabbit conjunctiva was established. © 2018 American Leather Chemists Association. All rights reserved.