Effects of quercetin on protective capacity in rats fed a high-fructose diet
Аксенов И. В., Аврен'ева Л. И., Гусева Г. В., Трусов Н. В., Балакина А. С., Мжел'скайа К. В., Сото C. Й., Кравченко Л. В., Тутельян В. А.
Вопросы питания
Т. 87, Вып. 5, С. 6-12
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.24411/0042-8833-2018-10047
Аннотация:
The purpose of the study was to determine effects of quercetin on protective capacity parameters in the experiment on rats fed a high fructose diet. Rats of the control group received a semi-synthetic (s/s) diet and water; animals from the P' experimental group-s/s diet and 20[%] fructose solution instead of drinking water; rats of the 2nd experimental group-s/s diet with quercetin (0.1[%] indiet) and 20[%] fructose solution instead of drinking water for 20 weeks. Parameters of antioxidant status [total antioxidant activity (AOA), the content of malondialdehyde (MDA) and lipids hydroperoxides, the level of reduced andoxidizedglutathione, activity of superoxide dismutase, catalase, glutathione peroxidase, paraoxonase-1, hemeoxygenase-1, NAD(P)H-quinone oxidoreductase], the activity of xenobiotic-metabolizing enzymes [CYP1A1, CYP1A2, CYP2B1, CYP3A, UDP-glucuronosyltransferase (UDP-GT) and glutathione transferase] were studied in plasma and liver of rats. Consumption of the high-fructose diet l
Ключевые слова:
Antioxidant enzymes; Fructose; Lysosomal enzymes; Quercetin; Xenobiotic-metabolizing enzymes
antioxidant; cytochrome P450; fructose; glutathione; quercetin; animal; blood; carbohydrate diet; drug effect; lipid peroxidation; male; metabolism; pharmacology; rat; Wistar rat; Animals; Antioxidants; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Fructose; Glutathione; Lipid Peroxidation; Male; Quercetin; Rats; Rats, Wistar
Язык текста: Русский
ISSN: 0042-8833
Аксенов И. В.
Аврен'ева Л. И.
Гусева Г. В.
Трусов Н. В.
Балакина А. С.
Мжел'скайа К. В.
Сото C. Й.
Кравченко Л. В.
Тутельян В. А. Виктор Александрович 1942-
Aksenov I. V.
Avren'eva L. I.
Guseva G. V.
Trusov N. V.
Balakina A. S.
Mzhel'skaya K. V.
Soto C. J.
Kravchenko L. V.
Tutel`yan V. A. Viktor Aleksandrovich 1942-
Effects of quercetin on protective capacity in rats fed a high-fructose diet
Текст визуальный непосредственный
Вопросы питания
Издательская группа "ГЭОТАР-Медиа"
Т. 87, Вып. 5 С. 6-12
2018
Статья
Antioxidant enzymes Fructose Lysosomal enzymes Quercetin Xenobiotic-metabolizing enzymes
antioxidant cytochrome P450 fructose glutathione quercetin animal blood carbohydrate diet drug effect lipid peroxidation male metabolism pharmacology rat Wistar rat Animals Antioxidants Cytochrome P-450 Enzyme System Dietary Carbohydrates Fructose Glutathione Lipid Peroxidation Male Quercetin Rats Rats, Wistar
The purpose of the study was to determine effects of quercetin on protective capacity parameters in the experiment on rats fed a high fructose diet. Rats of the control group received a semi-synthetic (s/s) diet and water; animals from the P' experimental group-s/s diet and 20[%] fructose solution instead of drinking water; rats of the 2nd experimental group-s/s diet with quercetin (0.1[%] indiet) and 20[%] fructose solution instead of drinking water for 20 weeks. Parameters of antioxidant status [total antioxidant activity (AOA), the content of malondialdehyde (MDA) and lipids hydroperoxides, the level of reduced andoxidizedglutathione, activity of superoxide dismutase, catalase, glutathione peroxidase, paraoxonase-1, hemeoxygenase-1, NAD(P)H-quinone oxidoreductase], the activity of xenobiotic-metabolizing enzymes [CYP1A1, CYP1A2, CYP2B1, CYP3A, UDP-glucuronosyltransferase (UDP-GT) and glutathione transferase] were studied in plasma and liver of rats. Consumption of the high-fructose diet l