Bulletin of Experimental Biology and Medicine
Vol.166, Issue3, P. 383-385
Аннотация:
The benign and malignant neoplasms in parotid gland have similar clinical presentations despite different tumor growth rates. The study compared the clinical and morphological data as well as the results of ELISA for MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in salivary fluid yielded during primary examination of the patients with pleomorphic adenoma and adenocarcinoma of parotid gland. The examined biomarkers detected in salivary fluid in patients with various cancer types differed significantly (p≤0.05). The correlations between clinical identification of adenoma or adenocarcinoma, on the one hand, and the levels of MMP-8, TIMP-1, and TIMP-2, on the other hand, makes it possible to use the latter as biomarkers for early detection and comprehensive noninvasive differential diagnostics of these neoplasms. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
adenocarcinoma; adenoma; neoplasm; parotid gland; saliva
biological marker; gelatinase A; gelatinase B; matrix metalloproteinase; neutrophil collagenase; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinase 2; gelatinase A; gelatinase B; MMP2 protein, human; MMP8 protein, human; MMP9 protein, human; neutrophil collagenase; TIMP1 protein, human; TIMP2 protein, human; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinase 2; tumor marker; Article; controlled study; enzyme linked immunosorbent assay; female; human; human tissue; major clinical study; male; parotid gland; parotid gland tumor; pleomorphic adenoma; saliva; adenocarcinoma; adenoma; case control study; chemistry; comparative study; differential diagnosis; early cancer diagnosis; gene expression; genetics; metabolism; middle aged; neoplasm; parotid gland tumor; pathology; Adenocarcinoma; Adenoma; Biomarkers, Tumor; Case-Control Studies; Diagnosis, Differential; Early Detection of Cancer; Female; Gene Expression; Humans; Male; Matrix M
Kochurova E. V.
Кочурова Е. В.
Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.166, Issue3 P. 383-385
2019
Статья
adenocarcinoma adenoma neoplasm parotid gland saliva
biological marker gelatinase A gelatinase B matrix metalloproteinase neutrophil collagenase tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 gelatinase A gelatinase B MMP2 protein, human MMP8 protein, human MMP9 protein, human neutrophil collagenase TIMP1 protein, human TIMP2 protein, human tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 tumor marker Article controlled study enzyme linked immunosorbent assay female human human tissue major clinical study male parotid gland parotid gland tumor pleomorphic adenoma saliva adenocarcinoma adenoma case control study chemistry comparative study differential diagnosis early cancer diagnosis gene expression genetics metabolism middle aged neoplasm parotid gland tumor pathology Adenocarcinoma Adenoma Biomarkers, Tumor Case-Control Studies Diagnosis, Differential Early Detection of Cancer Female Gene Expression Humans Male Matrix M
The benign and malignant neoplasms in parotid gland have similar clinical presentations despite different tumor growth rates. The study compared the clinical and morphological data as well as the results of ELISA for MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in salivary fluid yielded during primary examination of the patients with pleomorphic adenoma and adenocarcinoma of parotid gland. The examined biomarkers detected in salivary fluid in patients with various cancer types differed significantly (p≤0.05). The correlations between clinical identification of adenoma or adenocarcinoma, on the one hand, and the levels of MMP-8, TIMP-1, and TIMP-2, on the other hand, makes it possible to use the latter as biomarkers for early detection and comprehensive noninvasive differential diagnostics of these neoplasms. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.