Pregnancy protects the kidney from acute ischemic injury
Popkov V. A., Andrianova N. V., Manskikh V. N., Silachev D. N., Pevzner I. B., Zorova L. D., Sukhikh G. T., Plotnikov E. Yu., Zorov D. B.
Scientific Reports
Vol.8, Issue1, Num.14534
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1038/s41598-018-32801-8
Аннотация:
A complex analysis of acute kidney injury (AKI) in pregnant women shows that it is caused by the interaction of gestation-associated pathologies and beneficial signaling pathways activated by pregnancy. Studies report an increase in the regeneration of some organs during pregnancy. However, the kidney response to the injury during pregnancy has not been addressed. We investigated the mechanisms of the pregnancy influence on AKI. During pregnancy, the kidneys were shown to be more tolerant to AKI. Pregnant animals showed remarkable preservation of kidney functions after ischemia/reperfusion (I/R) indicated by the decrease of serum creatinine levels. The pregnant rats also demonstrated a significant decrease in kidney injury markers and an increase in protective markers. Two months after the I/R, group of pregnant animals had a decreased level of fibrosis in the kidney tissue. These effects are likely linked to increased cell proliferation after injury: using real-time cell proliferation
Ключевые слова:
acute kidney failure; animal; apoptosis; cell culture; cell proliferation; female; human; kidney; pathology; physiology; pregnancy; protection; rat; reperfusion injury; Acute Kidney Injury; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Female; Humans; Kidney; Pregnancy; Protective Factors; Rats; Reperfusion Injury
Язык текста: Английский
ISSN: 2045-2322
Popkov V. A.
Andrianova N. V.
Manskikh V. N.
Silachev D. N.
Pevzner I. B.
Zorova L. D.
Sukhikh G. T. Gennadij Tikhonovich 1947-
Plotnikov E. Yu. Egor Yuryevich 1980-
Zorov D. B.
Попков В. А.
Андрианова Н. В.
Манских В. Н.
Силачев Д. Н.
Певзнер И. Б.
Зорова Л. Д.
Сухих Г. Т. Геннадий Тихонович 1947-
Плотников Е. Ю. Егор Юрьевич 1980-
Зоров Д. Б.
Pregnancy protects the kidney from acute ischemic injury
Текст визуальный непосредственный
Scientific Reports
Vol.8, Issue1 Num.14534
2018
Статья
acute kidney failure animal apoptosis cell culture cell proliferation female human kidney pathology physiology pregnancy protection rat reperfusion injury Acute Kidney Injury Animals Apoptosis Cell Proliferation Cells, Cultured Female Humans Kidney Pregnancy Protective Factors Rats Reperfusion Injury
A complex analysis of acute kidney injury (AKI) in pregnant women shows that it is caused by the interaction of gestation-associated pathologies and beneficial signaling pathways activated by pregnancy. Studies report an increase in the regeneration of some organs during pregnancy. However, the kidney response to the injury during pregnancy has not been addressed. We investigated the mechanisms of the pregnancy influence on AKI. During pregnancy, the kidneys were shown to be more tolerant to AKI. Pregnant animals showed remarkable preservation of kidney functions after ischemia/reperfusion (I/R) indicated by the decrease of serum creatinine levels. The pregnant rats also demonstrated a significant decrease in kidney injury markers and an increase in protective markers. Two months after the I/R, group of pregnant animals had a decreased level of fibrosis in the kidney tissue. These effects are likely linked to increased cell proliferation after injury: using real-time cell proliferation