New criteria of radical surgery and long-term outcomes of hilar cholangiocarcinoma management [Novye kriterii radikal'nosti operatsiĭ i otdalennye...
Коваленко Y. А., Вишневскy В. А., Чжао А. В., Жариков Y. О.
Хирургия. Журнал им. Н.И. Пирогова
Вып. 8, С. 4-11
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.17116/hirurgia201884
Аннотация:
AIM: To develop new criteria of radical surgery for hilar cholangiocarcinoma (HCC). MATERIAL AND METHODS: There were 165 HCC patients who underwent surgery in 1986-2016 at the Vishnevsky Institute of Surgery. TNM stage distribution: stage I - 4 (2.4[%]), II - 45 (27.3[%]) (29 of them are referred to the 1st period of work), IIIA - 23 (13.9[%]), IIIB - 41 (24.8[%]), IVA - 35 (21.2[%]), IVB - 17 (10.3[%]). 80 (48[%]) patients underwent hemihepatectomy, 17 (10[%]) - advanced hemihepatectomy, 16 (10[%]) - minor liver resection with common bile duct repair, 52 (32[%]) - common bile duct repair resection. Kaplan-Meier survival analysis was performed. Cox proportional hazard model was applied to access relationship between survival and prognostic factors. Log-rank test was used to compare both survival curves. RESULTS: R0-resection as followed by 5-year survival rate near 32[%]. Microvascular invasion was observed in 42.9[%], lymphovascular invasion - in 88.2[%], positive resection margin - in 59.2[%], perineural invasi
Ключевые слова:
hilar cholangiocarcinoma; R-0 resection; surgical treatment
bile duct cancer; common bile duct; human; Klatskin tumor; liver resection; lymph node metastasis; mortality; pathology; procedures; retrospective study; survival analysis; treatment outcome; tumor invasion; Bile Duct Neoplasms; Common Bile Duct; Hepatectomy; Humans; Klatskin Tumor; Lymphatic Metastasis; Neoplasm Invasiveness; Retrospective Studies; Survival Analysis; Treatment Outcome
Язык текста: Русский
ISSN: 2309-5628
Коваленко Y. А.
Вишневскy В. А.
Чжао А. В.
Жариков Y. О.
Kovalenko Y. A.
Vishnevsky V. A.
Chzhao A. V.
Zharikov Y. O.
New criteria of radical surgery and long-term outcomes of hilar cholangiocarcinoma management [Novye kriterii radikal'nosti operatsiĭ i otdalennye rezul'taty lecheniia vorotnoĭ kholangiokartsinomy]
New criteria of radical surgery and long-term outcomes of hilar cholangiocarcinoma management [Novye kriterii radikal'nosti operatsiĭ i otdalennye...
Текст визуальный непосредственный
Хирургия. Журнал им. Н.И. Пирогова
Издательство Медиа Сфера
Вып. 8 С. 4-11
2018
Статья
hilar cholangiocarcinoma R-0 resection surgical treatment
bile duct cancer common bile duct human Klatskin tumor liver resection lymph node metastasis mortality pathology procedures retrospective study survival analysis treatment outcome tumor invasion Bile Duct Neoplasms Common Bile Duct Hepatectomy Humans Klatskin Tumor Lymphatic Metastasis Neoplasm Invasiveness Retrospective Studies Survival Analysis Treatment Outcome
AIM: To develop new criteria of radical surgery for hilar cholangiocarcinoma (HCC). MATERIAL AND METHODS: There were 165 HCC patients who underwent surgery in 1986-2016 at the Vishnevsky Institute of Surgery. TNM stage distribution: stage I - 4 (2.4[%]), II - 45 (27.3[%]) (29 of them are referred to the 1st period of work), IIIA - 23 (13.9[%]), IIIB - 41 (24.8[%]), IVA - 35 (21.2[%]), IVB - 17 (10.3[%]). 80 (48[%]) patients underwent hemihepatectomy, 17 (10[%]) - advanced hemihepatectomy, 16 (10[%]) - minor liver resection with common bile duct repair, 52 (32[%]) - common bile duct repair resection. Kaplan-Meier survival analysis was performed. Cox proportional hazard model was applied to access relationship between survival and prognostic factors. Log-rank test was used to compare both survival curves. RESULTS: R0-resection as followed by 5-year survival rate near 32[%]. Microvascular invasion was observed in 42.9[%], lymphovascular invasion - in 88.2[%], positive resection margin - in 59.2[%], perineural invasi