Аннотация:
Cardiovascular diseases (CVD) are the main cause of death worldwide. A broad study of the pathogenetic mechanisms of the CVD onset and progression has led to understanding of the importance of endothelial dysfunction (ED) in these processes. During recent years intensive work has been conducted in the direction of searching for markers of ED. Metabolomics is an intensively advancing approach to early diagnostics of diseases. Metabolomic analysis based on mass spectrometry allows to study complete metabolic profiles and their deviations resulting from changes in expression of genes and RNA, protein activity, or environmental factors. Metabolomic analysis has already demonstrated significant results in the solving of different scientific and clinical problems. It appears to be a promising method for detecting early biomarkers of CVD. Various aspects of application of metabolomic profiling in the field of cardiovascular diseases are discussed in this article. © 2018 Media Sphera Publishin
Беленков Ю. Н. Юрий Никитич 1948-
Привалова Е. В. Елена Витальевна 1958-
Кожевникова М. В. Мария Владимировна 1983-
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Ларcова Е. В.
Месонжник Н. В. Наталья Владимировна 1983-
Belenkov Yu. N. Yurij Nikitich 1948-
Privalova E. V. Elena Vitalyevna 1958-
Kozhevnikova M. V. Mariya Vladimirovna 1983-
Korobkova E. O.
Ilgisonins I. S.
Kaplunova V. Yu. Vera Yuryevna 1953-
Shakar`yants G. A. Gayane` Andronikovna 1985-
Appolonova S. A. Svetlana Aleksandrovna 1973-
Kuharenko A. V.
Larcova E. V.
Mesonzhnik N. V. Natal`ya Vladimirovna 1983-
Metabolomic profiling of patients with cardiovascular diseases
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Т. 58, Вып. 9 С. 59-62
2018
Статья
Cardio-vascular diseases Endothelial dysfunction Metabolomic profiling Metabolomics
biological marker blood cardiovascular disease human mass spectrometry metabolism metabolomics Biomarkers Cardiovascular Diseases Humans Mass Spectrometry Metabolomics
Cardiovascular diseases (CVD) are the main cause of death worldwide. A broad study of the pathogenetic mechanisms of the CVD onset and progression has led to understanding of the importance of endothelial dysfunction (ED) in these processes. During recent years intensive work has been conducted in the direction of searching for markers of ED. Metabolomics is an intensively advancing approach to early diagnostics of diseases. Metabolomic analysis based on mass spectrometry allows to study complete metabolic profiles and their deviations resulting from changes in expression of genes and RNA, protein activity, or environmental factors. Metabolomic analysis has already demonstrated significant results in the solving of different scientific and clinical problems. It appears to be a promising method for detecting early biomarkers of CVD. Various aspects of application of metabolomic profiling in the field of cardiovascular diseases are discussed in this article. © 2018 Media Sphera Publishin