Аннотация:
Purpose of the study. To examine the frequency and risk factors for the development of diastolic dysfunction (DD) of the left ventricle (LV) of the heart in patients with chronic kidney disease (CKD). Materials and methods. The study included 225 patients with stage I-CKD of non-diabetic etiology (median age 47.0 years, 50.2[%] of women). Depending on the degree of decrease in the glomerular filtration rate (GFR), all patients were divided into 3 groups. Group 1 (n=70) consisted of patients with GFR 89-45 ml / min / 1.73 m2, group 2 (n=120) - patients with GFR 44-15 ml / min / 1.73 m2, group 3 (n=35) - patients with GFR <15 mL / min / 1.73 m2. The control group includes persons without CKD. All patients underwent general clinical examination and transthoracic echocardiography; in 86 patients the level of cystatin C in the blood serum was determined. Results. Hypertrophy of the left ventricle (LVH) of the heart was detected in 87 (38.7[%]) of 225 patients with CKD. Hypertrophic type (type I
Ключевые слова:
chronic kidney disease.; diastolic left ventricular myocardium dysfunction
cystatin C; blood; chronic kidney failure; disease exacerbation; echocardiography; etiology; female; glomerulus filtration rate; heart left ventricle function; heart left ventricle hypertrophy; heart ventricle remodeling; human; incidence; male; middle aged; pathophysiology; patient acuity; procedures; risk factor; Russian Federation; Cystatin C; Disease Progression; Echocardiography; Female; Glomerular Filtration Rate; Humans; Hypertrophy, Left Ventricular; Incidence; Male; Middle Aged; Patient Acuity; Renal Insufficiency, Chronic; Risk Factors; Russia; Ventricular Dysfunction, Left; Ventricular Remodeling
Руденко Т. Е. Татьяна Евгеньевна 1975-
Камышова Е. С. Елена Сергеевна 1976-
Васильева М. П. Мария Павловна 1985-
Бобкова И. Н. Ирина Николаевна 1967-
Соломахина Н. И. Нина Иосифовна 1954-
Швецов М. Ю. Михаил Юрьевич 1967-
Rudenko T. E. Tat`yana Evgenyevna 1975-
Kamy'shova E. S. Elena Sergeevna 1976-
Vasilyeva M. P. Mariya Pavlovna 1985-
Bobkova I. N. Irina Nikolaevna 1967-
Solomakhina N. I. Nina Iosifovna 1954-
Shvetsov M. Yu. Mikhail Yuryevich 1967-
Risk factors for diastolic left ventricular myocardial dysfunction in patients with chronic kidney disease
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 9 С. 60-67
2018
Статья
chronic kidney disease. diastolic left ventricular myocardium dysfunction
cystatin C blood chronic kidney failure disease exacerbation echocardiography etiology female glomerulus filtration rate heart left ventricle function heart left ventricle hypertrophy heart ventricle remodeling human incidence male middle aged pathophysiology patient acuity procedures risk factor Russian Federation Cystatin C Disease Progression Echocardiography Female Glomerular Filtration Rate Humans Hypertrophy, Left Ventricular Incidence Male Middle Aged Patient Acuity Renal Insufficiency, Chronic Risk Factors Russia Ventricular Dysfunction, Left Ventricular Remodeling
Purpose of the study. To examine the frequency and risk factors for the development of diastolic dysfunction (DD) of the left ventricle (LV) of the heart in patients with chronic kidney disease (CKD). Materials and methods. The study included 225 patients with stage I-CKD of non-diabetic etiology (median age 47.0 years, 50.2[%] of women). Depending on the degree of decrease in the glomerular filtration rate (GFR), all patients were divided into 3 groups. Group 1 (n=70) consisted of patients with GFR 89-45 ml / min / 1.73 m2, group 2 (n=120) - patients with GFR 44-15 ml / min / 1.73 m2, group 3 (n=35) - patients with GFR <15 mL / min / 1.73 m2. The control group includes persons without CKD. All patients underwent general clinical examination and transthoracic echocardiography; in 86 patients the level of cystatin C in the blood serum was determined. Results. Hypertrophy of the left ventricle (LVH) of the heart was detected in 87 (38.7[%]) of 225 patients with CKD. Hypertrophic type (type I