Features of immunoregulation in patients with pulmonary tuberculosis with blood eosinophilia
Уразова О. И., Чурина Е. Г., Колобовникова Y. В., Новицкиy В. В., Караулов А. В., Никулина Е. Л., Полетика В. С.
Бюллетень сибирской медицины
Т. 17, Вып. 3, С. 168-179
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.20538/1682-0363-2018-3-168-179
Аннотация:
The aim of the investigation was to determine the characteristics of the immune response regulation for pulmonary tuberculosis (TB) and to analyze the role of regulatory T cells in the immunopathogenesis of TB with eosinophilia in the blood, depending on the clinical form of the disease and sensitivity of Micobacterium tuberculosis to anti-TB drugs. Materials and methods. 157 patients who were initially diagnosed with infiltrative and disseminated TB were examined. The material of the study was venous blood and culture of mononuclear leukocytes isolated from venous blood. The content of interleukin (IL) 4, IL-10 and transforming factor beta (TGFβ) in culture suspensions of mononuclear leukocytes in vitro and IL-5 in the blood was determined by enzyme-linked immunosorbent assay (ELISA) test. The expression of surface molecules CD4, CD20, CD25 and intracellular transcription factor Foxp3 by lymphocytes of the blood was evaluated by flow cytometry. The obtained results were analyzed by st
Ключевые слова:
Eosinophilia; Immune response regulation; Pulmonary tuberculosis; Regulatory T cells
Язык текста: Русский
ISSN: 1819-3684
Уразова О. И.
Чурина Е. Г.
Колобовникова Y. В. Ю.В.
Новицкиy В. В.
Караулов А. В. Александр Викторович 1953-
Никулина Е. Л.
Полетика В. С.
Urazova O. I.
Churina E. G.
Kolobovnikova Y. V. Yu.V.
Novitskiy V. V.
Karaulov A. V. Aleksandr Viktorovich 1953-
Nikulina E. L.
Poletika V. S.
Features of immunoregulation in patients with pulmonary tuberculosis with blood eosinophilia
Текст визуальный непосредственный
Бюллетень сибирской медицины
Сибирский государственный медицинский университет
Т. 17, Вып. 3 С. 168-179
2018
Статья
Eosinophilia Immune response regulation Pulmonary tuberculosis Regulatory T cells
The aim of the investigation was to determine the characteristics of the immune response regulation for pulmonary tuberculosis (TB) and to analyze the role of regulatory T cells in the immunopathogenesis of TB with eosinophilia in the blood, depending on the clinical form of the disease and sensitivity of Micobacterium tuberculosis to anti-TB drugs. Materials and methods. 157 patients who were initially diagnosed with infiltrative and disseminated TB were examined. The material of the study was venous blood and culture of mononuclear leukocytes isolated from venous blood. The content of interleukin (IL) 4, IL-10 and transforming factor beta (TGFβ) in culture suspensions of mononuclear leukocytes in vitro and IL-5 in the blood was determined by enzyme-linked immunosorbent assay (ELISA) test. The expression of surface molecules CD4, CD20, CD25 and intracellular transcription factor Foxp3 by lymphocytes of the blood was evaluated by flow cytometry. The obtained results were analyzed by st