Gastroenterology and Hepatology from Bed to Bench
Vol.11, Issue4, P. 325-332
Аннотация:
Aim: To assess NT-proBNP as a biomarker for hyperdynamic circulation in decompensated cirrhosis. Background: Hyperdynamic circulation is common in decompensated cirrhosis. The previous studies reveal that N-terminal-proBNP (NT-proBNP) is elevated in cirrhosis. Methods: A prospective study involved 47 patients with decompensated cirrhosis. All of them underwent echocardiography with simultaneous measurement of blood pressure and heart rate. Cardiac output and systemic vascular resistance were calculated. The concentration of NT-proBNP in blood was measured with enzyme-linked immunosorbent assay. Results: In patients with decompensated cirrhosis, the concentration of NT-proBNP in blood directly correlated with end-diastolic volume (r=0.482; p<0.001), stroke volume (r= 0.566; p<0.001), cardiac output (r=0.556; p<0.001), volume of the left atrium (r=0.292; p=0.047), and inversely correlated with systemic vascular resistance (r=-0.538; p<0.001). There was no significant correlation between
Maslennikov R. V. Roman Vyacheslavovich 1984-
Driga A. A. Anastasiya Aleksandrovna 0001-
Ivashkin K.
Ivashkin V. T. Vladimir Trofimovich 1939-
Масленников Р. В. Роман Вячеславович 1984-
Дрига А. А. Анастасия Александровна 0001-
Ивашкин К.
Ивашкин В. Т. Владимир Трофимович 1939-
NT-proBNP as a biomarker for hyperdynamic circulation in decompensated cirrhosis
Текст визуальный непосредственный
Gastroenterology and Hepatology from Bed to Bench
Vol.11, Issue4 P. 325-332
2018
Статья
Biomarkers Blood circulation Brain Liver cirrhosis Natriuretic peptide
Aim: To assess NT-proBNP as a biomarker for hyperdynamic circulation in decompensated cirrhosis. Background: Hyperdynamic circulation is common in decompensated cirrhosis. The previous studies reveal that N-terminal-proBNP (NT-proBNP) is elevated in cirrhosis. Methods: A prospective study involved 47 patients with decompensated cirrhosis. All of them underwent echocardiography with simultaneous measurement of blood pressure and heart rate. Cardiac output and systemic vascular resistance were calculated. The concentration of NT-proBNP in blood was measured with enzyme-linked immunosorbent assay. Results: In patients with decompensated cirrhosis, the concentration of NT-proBNP in blood directly correlated with end-diastolic volume (r=0.482; p<0.001), stroke volume (r= 0.566; p<0.001), cardiac output (r=0.556; p<0.001), volume of the left atrium (r=0.292; p=0.047), and inversely correlated with systemic vascular resistance (r=-0.538; p<0.001). There was no significant correlation between