The dopaminergic dysfunction and altered working memory performance of aging mice lacking gamma-synuclein gene
Kokhan V. S., Kokhan T. G., Samsonova A. N., Fisenko V. P., Ustyugov A. A., Aliev G.
CNS & Neurological Disorders - Drug Targets
Vol.17, Issue8, P. 604-607
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.2174/1871527317666180726095734
Аннотация:
Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice. Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals. Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice. Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained. Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory. © 2018 Bentham Science Publishers.
Ключевые слова:
And amphetamine induced locomotion; Gamma-synuclein; Neural tissue; Passive-avoidance test; Soluble proteins; Working memory
amphetamine; dopamine; dopamine transporter; gamma synuclein; amphetamine; dopamine; dopamine receptor stimulating agent; gamma synuclein; aging; animal experiment; animal model; Article; cognition; controlled study; dopaminergic activity; dopaminergic nerve cell; gamma synuclein gene; gene; latent period; locomotion; male; mouse; nonhuman; passive avoidance test; synapse vesicle; synaptic transmission; working memory; aging; animal; avoidance behavior; C57BL mouse; disease model; drug effect; genetics; memory disorder; metabolism; physiology; reaction time; short term memory; transgenic mouse; Aging; Amphetamine; Animals; Avoidance Learning; Disease Models, Animal; Dopamine; Dopamine Agents; gamma-Synuclein; Locomotion; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reaction Time
Язык текста: Английский
ISSN: 1996-3181
Kokhan V. S.
Kokhan T. G.
Samsonova A. N.
Fisenko V. P. Vladimir Petrovich 1946-
Ustyugov A. A.
Aliev G. Gyumrakh 1958-
Кохан В. С.
Кохан Т. Г.
Самсонова А. Н.
Фисенко В. П. Владимир Петрович 1946-
Устюгов А. А.
Алиев Г. Гюмрах 1958-
The dopaminergic dysfunction and altered working memory performance of aging mice lacking gamma-synuclein gene
Текст визуальный непосредственный
CNS & Neurological Disorders - Drug Targets
Bentham Science Publishers
Vol.17, Issue8 P. 604-607
2018
Статья
And amphetamine induced locomotion Gamma-synuclein Neural tissue Passive-avoidance test Soluble proteins Working memory
amphetamine dopamine dopamine transporter gamma synuclein amphetamine dopamine dopamine receptor stimulating agent gamma synuclein aging animal experiment animal model Article cognition controlled study dopaminergic activity dopaminergic nerve cell gamma synuclein gene gene latent period locomotion male mouse nonhuman passive avoidance test synapse vesicle synaptic transmission working memory aging animal avoidance behavior C57BL mouse disease model drug effect genetics memory disorder metabolism physiology reaction time short term memory transgenic mouse Aging Amphetamine Animals Avoidance Learning Disease Models, Animal Dopamine Dopamine Agents gamma-Synuclein Locomotion Memory Disorders Memory, Short-Term Mice Mice, Inbred C57BL Mice, Transgenic Reaction Time
Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice. Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals. Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice. Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained. Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory. © 2018 Bentham Science Publishers.