Factors influencing the efficiency of therapy in patients with rheumatoid arthritis: The role of comorbid mental and somatic diseases
Абрамкин А. А., Лисицyна Т. А., Велтишчев Д. Y., Серавина О. Ф., Ковалевскайа О. Б., Глухова С. И., Насонов Е. Л.
Научно-практическая ревматология
Т. 56, Вып. 4, С. 439-448
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.14412/1995-4484-2018-439-448
Аннотация:
The response rate to therapy for rheumatoid arthritis (RA) rarely exceeds 60[%]. Mental disorders (MDs) of the anxiety-depressive spectrum (ADS) and cognitive impairment (CI) substantially affect the evaluation of the efficiency of RA therapy. Adequate psychopharmacotherapy is one of the possible approaches to optimizing the treatment of RA. The factors influencing the efficiency of RA therapy with standard disease-modifying antirheumatic drugs (DMARDs) and biological agents (BAs) in combination with adequate psychopharmacotherapy have not been previously identified. Objective: to determine the predictors of response to therapy in patients with RA receiving DMARDs and BAs with or without adequate psychopharmacotherapy for ADS disorders. Subjects and methods. The investigation included 128 patients (13[%] men and 87[%] women) with a reliable diagnosis of RA. At baseline, 75.1[%] of patients received DMARDs; 7.8[%] - BAs. ADS disorders were detected in 123 (96.1[%]) patients. Psychopharmacotherapy w
Ключевые слова:
Biological agents; Disease-modifying antirheumatic drugs; Efficiency of therapy; Mental disorders; Predictors; Psychopharmacotherapy; Rheumatoid arthritis; Therapy adherence
Язык текста: Русский
ISSN: 1995-4492
Абрамкин А. А.
Лисицyна Т. А.
Велтишчев Д. Y. Д.Ю.
Серавина О. Ф.
Ковалевскайа О. Б.
Глухова С. И.
Насонов Е. Л. Евгений Львович 1948-
Abramkin A. A.
Lisitsyna T. A.
Veltishchev D. Y. D.Yu.
Seravina O. F.
Kovalevskaya O. B.
Glukhova S. I.
Nasonov E. L. Evgenij L`vovich 1948-
Factors influencing the efficiency of therapy in patients with rheumatoid arthritis: The role of comorbid mental and somatic diseases
Текст визуальный непосредственный
Научно-практическая ревматология
ИМА-Пресс
Т. 56, Вып. 4 С. 439-448
2018
Статья
Biological agents Disease-modifying antirheumatic drugs Efficiency of therapy Mental disorders Predictors Psychopharmacotherapy Rheumatoid arthritis Therapy adherence
The response rate to therapy for rheumatoid arthritis (RA) rarely exceeds 60[%]. Mental disorders (MDs) of the anxiety-depressive spectrum (ADS) and cognitive impairment (CI) substantially affect the evaluation of the efficiency of RA therapy. Adequate psychopharmacotherapy is one of the possible approaches to optimizing the treatment of RA. The factors influencing the efficiency of RA therapy with standard disease-modifying antirheumatic drugs (DMARDs) and biological agents (BAs) in combination with adequate psychopharmacotherapy have not been previously identified. Objective: to determine the predictors of response to therapy in patients with RA receiving DMARDs and BAs with or without adequate psychopharmacotherapy for ADS disorders. Subjects and methods. The investigation included 128 patients (13[%] men and 87[%] women) with a reliable diagnosis of RA. At baseline, 75.1[%] of patients received DMARDs; 7.8[%] - BAs. ADS disorders were detected in 123 (96.1[%]) patients. Psychopharmacotherapy w