The use of microfluidic technology for cancer applications and liquid biopsy
Kulasinghe A., Wu H., Punyadeera C., Ibragimi V. M. M.
Micromachines
Vol.9, Issue8, Num.397
Опубликовано: 2018
Тип ресурса: Обзор
Аннотация:
There is growing awareness for the need of early diagnostic tools to aid in point-of-care testing in cancer. Tumor biopsy remains the conventional means in which to sample a tumor and often presents with challenges and associated risks. Therefore, alternative sources of tumor biomarkers is needed. Liquid biopsy has gained attention due to its non-invasive sampling of tumor tissue and ability to serially assess disease via a simple blood draw over the course of treatment. Among the leading technologies developing liquid biopsy solutions, microfluidics has recently come to the fore. Microfluidic platforms offer cellular separation and analysis platforms that allow for high throughout, high sensitivity and specificity, low sample volumes and reagent costs and precise liquid controlling capabilities. These characteristics make microfluidic technology a promising tool in separating and analyzing circulating tumor biomarkers for diagnosis, prognosis and monitoring. In this review, the charac
Ключевые слова:
Cancer; Circulating biomarkers; Lab on a chip; Liquid biopsy; Microfluidic; Separation
Biomarkers; Biopsy; Diseases; Lab-on-a-chip; Liquids; Separation; Tumors; Alternative source; Cancer; Circulating tumor cells; Leading technology; Microfluidic platforms; Microfluidic technologies; Point-of-care testing; Tumor biomarkers; Microfluidics
Язык текста: Английский
ISSN: 2072-666X
Kulasinghe A.
Wu H.
Punyadeera C.
Ibragimi V. M. M. Varkiani Madzhid Modzhtaba 1983-
Куласингхе А.
Wу Х.
Пунядеера C.
Ибрагими В. М. М. Варкиани Маджид Моджтаба 1983-
The use of microfluidic technology for cancer applications and liquid biopsy
Текст визуальный непосредственный
Micromachines
Vol.9, Issue8 Num.397
2018
Обзор
Cancer Circulating biomarkers Lab on a chip Liquid biopsy Microfluidic Separation
Biomarkers Biopsy Diseases Lab-on-a-chip Liquids Separation Tumors Alternative source Cancer Circulating tumor cells Leading technology Microfluidic platforms Microfluidic technologies Point-of-care testing Tumor biomarkers Microfluidics
There is growing awareness for the need of early diagnostic tools to aid in point-of-care testing in cancer. Tumor biopsy remains the conventional means in which to sample a tumor and often presents with challenges and associated risks. Therefore, alternative sources of tumor biomarkers is needed. Liquid biopsy has gained attention due to its non-invasive sampling of tumor tissue and ability to serially assess disease via a simple blood draw over the course of treatment. Among the leading technologies developing liquid biopsy solutions, microfluidics has recently come to the fore. Microfluidic platforms offer cellular separation and analysis platforms that allow for high throughout, high sensitivity and specificity, low sample volumes and reagent costs and precise liquid controlling capabilities. These characteristics make microfluidic technology a promising tool in separating and analyzing circulating tumor biomarkers for diagnosis, prognosis and monitoring. In this review, the charac