Аннотация:
Objective: The problem of drug interactions is increasingly important today because they may induce serious adverse events as well as interfere with efficacy of pharmacotherapy. Combinations of drugs are most often prescribed to patients presenting with comorbid pathology. The incidence of a combination of arterial hypertension (AH) and acid-dependent diseases (ADDs) varies widely ranging from 11.6 to 50[%]. One of combinations of drugs prescribed to such patients is a combination of calcium channel blocker amlodipine and proton pump inhibitor omeprazole. The latter in the human body undergoes biotransformation mediated at the level of cytochrome P450 by isoenzymes CYP2C19 and CYP3A4. Amlodipine is a substrate of the isoenzyme CYP3A4, which increases the probability of the development of interaction between these drugs. The purpose of our study was to investigate antihypertensive efficacy of amlodipine in patients suffering from arterial hypertension combined with acid-dependent diseases
Dorofeeva M. N.
Shikh E. V. Evgeniya Valeryevna 1962-
Sizova Zh. M. Zhanna Mikhaylovna 1959-
Shindryaeva N. N. Natal`ya Nikolaevna 1976-
Lapidus N. I. Natal`ya Il`inichna 1972-
Дорофеева М. Н.
Ших Е. В. Евгения Валерьевна 1962-
Сизова Ж. М. Жанна Михайловна 1959-
Шиндряева Н. Н. Наталья Николаевна 1976-
Лапидус Н. И. Наталья Ильинична 1972-
Effect of omeprazole on antihypertensive efficacy of amlodipine in patients with comorbid pathology – arterial hypertension and acid-dependent disease
Текст визуальный непосредственный
Electronic Journal of General Medicine
Modestum Ltd.
Vol.15, Issue4
2018
Статья
Acid-dependent diseases Amlodipine Arterial hypertension Isoenzyme cyp 3a4 Omeprazole
Objective: The problem of drug interactions is increasingly important today because they may induce serious adverse events as well as interfere with efficacy of pharmacotherapy. Combinations of drugs are most often prescribed to patients presenting with comorbid pathology. The incidence of a combination of arterial hypertension (AH) and acid-dependent diseases (ADDs) varies widely ranging from 11.6 to 50[%]. One of combinations of drugs prescribed to such patients is a combination of calcium channel blocker amlodipine and proton pump inhibitor omeprazole. The latter in the human body undergoes biotransformation mediated at the level of cytochrome P450 by isoenzymes CYP2C19 and CYP3A4. Amlodipine is a substrate of the isoenzyme CYP3A4, which increases the probability of the development of interaction between these drugs. The purpose of our study was to investigate antihypertensive efficacy of amlodipine in patients suffering from arterial hypertension combined with acid-dependent diseases