Аннотация:
Traditionally, Parkinson’s disease (PD) is associated with the lesion of the substantia nigra and dopamine system dysfunction. However, current studies show the involvement of other CNS regions, which extend far beyond the substantia nigra, in the pathogenesis of PD. The prevalence of altered α-synuclein in PD leads to the dysfunction of several neurotransmitter systems including the orexin system located in the hypothalamus. The involvement of this system in the neurodegenerative process explains some symptoms of PD including daily drowsiness and eating disorders. The authors consider the pathophysiology of the orexin system and its role in the pathogenesis of PD. © 2018, Media Sphera Publishing Group. All rights reserved.
Ключевые слова:
Orexin system; Parkinson’s disease; Pathogenesis
alpha synuclein; orexin; alpha synuclein; dopamine; orexin; Article; central nervous system; drowsiness; eating disorder; hypothalamus; Parkinson disease; pathogenesis; pathophysiology; substantia nigra; human; alpha-Synuclein; Dopamine; Humans; Orexins; Parkinson Disease; Substantia Nigra
Яковлева О. В.
Ляшенко Е. А. Елена Александровна 0001-
Полуэктов М. Г. Михаил Гурьевич 1969-
Yakovleva O. V.
Lyashenko E. A. Elena Aleksandrovna 0001-
Polue`ktov M. G. Mikhail Guryevich 1969-
Dysfunction of the orexin system in parkinson’s disease
Текст визуальный непосредственный
Журнал неврологии и психиатрии им. C.C. Корсакова
Издательство Медиа Сфера
Т. 118, Вып. 6 С. 82-89
2018
Статья
Orexin system Parkinson’s disease Pathogenesis
alpha synuclein orexin alpha synuclein dopamine orexin Article central nervous system drowsiness eating disorder hypothalamus Parkinson disease pathogenesis pathophysiology substantia nigra human alpha-Synuclein Dopamine Humans Orexins Parkinson Disease Substantia Nigra
Traditionally, Parkinson’s disease (PD) is associated with the lesion of the substantia nigra and dopamine system dysfunction. However, current studies show the involvement of other CNS regions, which extend far beyond the substantia nigra, in the pathogenesis of PD. The prevalence of altered α-synuclein in PD leads to the dysfunction of several neurotransmitter systems including the orexin system located in the hypothalamus. The involvement of this system in the neurodegenerative process explains some symptoms of PD including daily drowsiness and eating disorders. The authors consider the pathophysiology of the orexin system and its role in the pathogenesis of PD. © 2018, Media Sphera Publishing Group. All rights reserved.