Evaluation of nephrocerebral risk with the use of cystatin C in patients with chronic kidney disease
Муркамилов И. Т., Сабиров И. С., Фомин В. В., Муркамилова Й. А., Аитбаев К. А., Райимжанов З. Р.
Журнал неврологии и психиатрии им. C.C. Корсакова
Т. 118, Вып. 9, С. 10-16
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.17116/jnevro201811809110
Аннотация:
Objective. To study a role of cystatin C in the nephrocerebral risk in chronic kidney disease at the initial stage of the disease. Material and methods. One hundred and twenty-eight patients (63 men and 65 women) with chronic kidney disease (CKD) were examined at the pre-dialysis stage of the disease. All patients underwent a complex clinical and laboratory examination with determination of the lipid spectrum, uric acid, fibrinogen, calcium and cystatin C, and subsequent calculation of the glomerular filtration rate (GFR). To assess structural changes in carotid arteries, ultrasound dopplerography was performed. Depending on the thickness of the intima-media (TIM), the entire sample is divided into CKD groups with no signs of carotid atherosclerosis (SC), n=70 and on CKD with SC, n=58. Results. Patients of the second group (CKD with SC), had higher body mass index (p<0.05), systolic (p<0.05) and central (p<0.05) arterial pressure (BP) and blood cystatin C (p<0.05). In the same group, t
Ключевые слова:
Cerebrovascular diseases; Chronic kidney disease; Cystatin C; Thickness of intima-media
calcium; cystatin C; fibrinogen; lipid; uric acid; cystatin C; arterial pressure; arterial wall thickness; artery malformation; Article; body mass; carotid artery; carotid atherosclerosis; chronic kidney failure; clinical examination; comparative study; dialysis; diastolic blood pressure; Doppler ultrasonography; drug blood level; drug safety; female; glomerulus filtration rate; high density lipoprotein cholesterol level; human; laboratory test; major clinical study; male; nephrocerebral risk; risk; risk assessment; systolic blood pressure; blood pressure; chronic kidney failure; Blood Pressure; Carotid Arteries; Cystatin C; Female; Glomerular Filtration Rate; Humans; Male; Renal Insufficiency, Chronic
Язык текста: Русский
ISSN: 2309-4729
Муркамилов И. Т.
Сабиров И. С.
Фомин В. В. Виктор Викторович 1978-
Муркамилова Й. А.
Аитбаев К. А.
Райимжанов З. Р.
Murkamilov I. T.
Sabirov I. S.
Fomin V. V. Viktor Viktorovich 1978-
Murkamilova J. A.
Aitbaev K. A.
Rayimzhanov Z. R.
Evaluation of nephrocerebral risk with the use of cystatin C in patients with chronic kidney disease
Текст визуальный непосредственный
Журнал неврологии и психиатрии им. C.C. Корсакова
Издательство Медиа Сфера
Т. 118, Вып. 9 С. 10-16
2018
Статья
Cerebrovascular diseases Chronic kidney disease Cystatin C Thickness of intima-media
calcium cystatin C fibrinogen lipid uric acid cystatin C arterial pressure arterial wall thickness artery malformation Article body mass carotid artery carotid atherosclerosis chronic kidney failure clinical examination comparative study dialysis diastolic blood pressure Doppler ultrasonography drug blood level drug safety female glomerulus filtration rate high density lipoprotein cholesterol level human laboratory test major clinical study male nephrocerebral risk risk risk assessment systolic blood pressure blood pressure chronic kidney failure Blood Pressure Carotid Arteries Cystatin C Female Glomerular Filtration Rate Humans Male Renal Insufficiency, Chronic
Objective. To study a role of cystatin C in the nephrocerebral risk in chronic kidney disease at the initial stage of the disease. Material and methods. One hundred and twenty-eight patients (63 men and 65 women) with chronic kidney disease (CKD) were examined at the pre-dialysis stage of the disease. All patients underwent a complex clinical and laboratory examination with determination of the lipid spectrum, uric acid, fibrinogen, calcium and cystatin C, and subsequent calculation of the glomerular filtration rate (GFR). To assess structural changes in carotid arteries, ultrasound dopplerography was performed. Depending on the thickness of the intima-media (TIM), the entire sample is divided into CKD groups with no signs of carotid atherosclerosis (SC), n=70 and on CKD with SC, n=58. Results. Patients of the second group (CKD with SC), had higher body mass index (p<0.05), systolic (p<0.05) and central (p<0.05) arterial pressure (BP) and blood cystatin C (p<0.05). In the same group, t