Comparative morphological characteristics and immunophenotype of urothelial carcinomas of the renal pelvis and bladder
Османов Ю. И. О., Гаибов З. А., Коган Е. А., Раденска-Лоповок С. Г., Тюрсунов К. З.
Архив патологии
Т. 80, Вып. 5, С. 23-32
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.17116/patol20188005123
Аннотация:
Urothelial carcinoma is one of the most frequently diagnosed malignant tumors of the bladder and upper urinary tract, which ranks seventh in the pattern of cancer. Urothelial carcinoma of the renal pelvis is less common; but has a more aggressive clinical course and a worse prognosis than that of the bladder. This is due to the clinical and morphological features of this form of cancer, which, unlike bladder cancer, have not been studied enough. Objective — to comparatively analyze the morphological and immunophenotypic parameters of urothelial carcinomas of the renal pelvis and bladder. Subject and methods. Surgical specimens from 196 patients diagnosed with urothelial carcinoma of the renal pelvis and bladder were investigated. Paraffin sections were immunohistochemically examined using the standard protocol. Antibodies against CK5/6, CD138, CDX2 (≪Dako≫), CK7, CK14, CK20, CEA, CD10, CD117, EMA, E-Cadherin, HMWCK, p63, Uroplakin III, Vimentin (≪Novocastra≫), CD44, GATA-3, MUC1, MUC2,
Ключевые слова:
Bladder; Immunoprofile; Renal pelvis; Urothelial carcinoma
tumor marker; bladder tumor; human; immunology; immunophenotyping; kidney pelvis; kidney tumor; transitional cell carcinoma; Biomarkers, Tumor; Carcinoma, Transitional Cell; Humans; Immunophenotyping; Kidney Neoplasms; Kidney Pelvis; Urinary Bladder Neoplasms
Язык текста: Русский
ISSN: 2309-1266
Османов Ю. И. О. Юсиф Ислам Оглы 1975-
Гаибов З. А.
Коган Е. А. Евгения Алтаровна 1951-
Раденска-Лоповок С. Г. Стефка Господинова 1951-
Тюрсунов К. З.
Osmanov Yu. I. O. Yusif Islam Ogly' 1975-
Gaibov Z. A.
Kogan E. A. Evgeniya Altarovna 1951-
Radenska-Lopovok S. G. Stefka Gospodinova 1951-
Tursunov K. Z.
Comparative morphological characteristics and immunophenotype of urothelial carcinomas of the renal pelvis and bladder
Текст визуальный непосредственный
Архив патологии
Издательство Медиа Сфера
Т. 80, Вып. 5 С. 23-32
2018
Статья
Bladder Immunoprofile Renal pelvis Urothelial carcinoma
tumor marker bladder tumor human immunology immunophenotyping kidney pelvis kidney tumor transitional cell carcinoma Biomarkers, Tumor Carcinoma, Transitional Cell Humans Immunophenotyping Kidney Neoplasms Kidney Pelvis Urinary Bladder Neoplasms
Urothelial carcinoma is one of the most frequently diagnosed malignant tumors of the bladder and upper urinary tract, which ranks seventh in the pattern of cancer. Urothelial carcinoma of the renal pelvis is less common; but has a more aggressive clinical course and a worse prognosis than that of the bladder. This is due to the clinical and morphological features of this form of cancer, which, unlike bladder cancer, have not been studied enough. Objective — to comparatively analyze the morphological and immunophenotypic parameters of urothelial carcinomas of the renal pelvis and bladder. Subject and methods. Surgical specimens from 196 patients diagnosed with urothelial carcinoma of the renal pelvis and bladder were investigated. Paraffin sections were immunohistochemically examined using the standard protocol. Antibodies against CK5/6, CD138, CDX2 (≪Dako≫), CK7, CK14, CK20, CEA, CD10, CD117, EMA, E-Cadherin, HMWCK, p63, Uroplakin III, Vimentin (≪Novocastra≫), CD44, GATA-3, MUC1, MUC2,