Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages
Dhanjal N. I., Sharma S., Skal`ny'j A. V., Skal`naya M. G., Aysuvakova O. P., Tin`kov A. A., Zhang F., Guo X., Prabhu K. S., Tejo P. N.
Food and Function
Vol.10, Issue5, P. 2839-2846
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
Cell signaling is necessary for the organs to co-ordinate with the whole body and it includes response to external stimuli, inflammation, hormonal secretions and other various metabolic functions. In the present study, we have focused on the inflammatory signals modulated by the reactive oxygen and nitrogen species (RONS). Under homeostatic conditions, these species turn on the COX-1-dependent arachidonic acid (AA) pathway towards the release of anti-inflammatory enzymes. However, the excess release of these ions induces negative effects in the form of inflammation by turning on the COX-2-dependent AA pathway to release pro-inflammatory enzymes. In the present study, we observed the shunting of the COX-2-dependent AA pathway towards the release of anti-inflammatory enzymes with the supplementation of organic dietary selenium in the form of seleniferous maize extracts. We observed that 500 nM selenium concentration in Se-maize extracts downregulated the COX-2 and mPGES-1 expressions by
Ключевые слова:
Ascorbic acid; Cell signaling; Dietary supplements; Enzymes; Pathology; Selenium; Anti-inflammatories; Arachidonic acids; External stimulus; Hormonal secretions; Lipopolysaccharides; Metabolic function; Reactive oxygen and nitrogen species; Selenium concentrations; Gene expression; arachidonic acid; cyclooxygenase 2; lipopolysaccharide; prostaglandin; prostaglandin E synthase; Ptges protein, mouse; selenium; animal; chemistry; drug effect; gene expression; genetics; macrophage; maize; metabolism; mouse; RAW 264.7 cell line; Animals; Arachidonic Acid; Cyclooxygenase 2; Gene Expression; Lipopolysaccharides; Macrophages; Mice; Prostaglandin-E Synthases; Prostaglandins; RAW 264.7 Cells; Selenium; Zea mays
Язык текста: Английский
ISSN: 2042-650X
Dhanjal N. I.
Sharma S.
Skal`ny'j A. V. Anatolij Viktorovich 1962-
Skal`naya M. G. Margarita Gennadievna 1968-
Aysuvakova O. P. Ol`ga Pavlovna 1982-
Tin`kov A. A. Aleksej Alekseevich 1989-
Zhang F.
Guo X.
Prabhu K. S.
Tejo P. N. Prakash N.
Дханйал Н. И.
Шарма С.
Скальный А. В. Анатолий Викторович 1962-
Скальная М. Г. Маргарита Геннадиевна 1968-
Айсувакова О. П. Ольга Павловна 1982-
Тиньков А. А. Алексей Алексеевич 1989-
Жанг Ф.
Гуо Х.
Прабху К. С.
Тейо П. Н. Пракаш Н.
Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages
Текст визуальный непосредственный
Food and Function
Vol.10, Issue5 P. 2839-2846
2019
Статья
Ascorbic acid Cell signaling Dietary supplements Enzymes Pathology Selenium Anti-inflammatories Arachidonic acids External stimulus Hormonal secretions Lipopolysaccharides Metabolic function Reactive oxygen and nitrogen species Selenium concentrations Gene expression arachidonic acid cyclooxygenase 2 lipopolysaccharide prostaglandin prostaglandin E synthase Ptges protein, mouse selenium animal chemistry drug effect gene expression genetics macrophage maize metabolism mouse RAW 264.7 cell line Animals Arachidonic Acid Cyclooxygenase 2 Gene Expression Lipopolysaccharides Macrophages Mice Prostaglandin-E Synthases Prostaglandins RAW 264.7 Cells Selenium Zea mays
Cell signaling is necessary for the organs to co-ordinate with the whole body and it includes response to external stimuli, inflammation, hormonal secretions and other various metabolic functions. In the present study, we have focused on the inflammatory signals modulated by the reactive oxygen and nitrogen species (RONS). Under homeostatic conditions, these species turn on the COX-1-dependent arachidonic acid (AA) pathway towards the release of anti-inflammatory enzymes. However, the excess release of these ions induces negative effects in the form of inflammation by turning on the COX-2-dependent AA pathway to release pro-inflammatory enzymes. In the present study, we observed the shunting of the COX-2-dependent AA pathway towards the release of anti-inflammatory enzymes with the supplementation of organic dietary selenium in the form of seleniferous maize extracts. We observed that 500 nM selenium concentration in Se-maize extracts downregulated the COX-2 and mPGES-1 expressions by