Аннотация:
Helminth infestations, including trematodoses, are a group of the most common diseases in the world. Trematodoses cause significant damage to human health, lead to various complications, which also causes significant economic damage. To develop effective anthelmintic drugs, it is necessary to study the structure and physiology of parasites and interaction with the host body. To create specific anthelmintic drugs, it is necessary to study the features of biochemistry and molecular biology of the structural components of the covers of trematodes. The is important role of the tegument in the evasion of the immune response. The trematode tegument antigens are good candidates for the development of anthelmintic vaccines. It is important to study the trematode genome and identify specific enzyme systems. Proteases of tegument of trematodes are digestive enzymes that can destroy the immunoglobulins of the host to modulate the immune response. Identification of specific differences in protein
Ларина С. Н. Светлана Николаевна 1965-
Бурдаев Н. И. Николай Игоревич 1994-
Беречикидзе И. А. Иза Автандиловна 1962-
Лазарева Ю. Б. Юлия Борисовна 1971-
Дегтяревская Т. Ю. Татьяна Юрьевна 1958-
Larina S. N. Svetlana Nikolaevna 1965-
Burdaev N. I. Nikolay Igorevich 1994-
Berechikidze I. A. Iza Avtandilovna 1962-
Lazareva Yu. B. Yuliya Borisovna 1971-
Degtyarevskaya T. Yu. Tat`yana Yuryevna 1958-
STRUCTURAL, MOLECULAR AND FUNCTIONAL FEATURES OF THE TREMATODE TEGUMENT AND OF ANTHELMINTIC DRUGS DEVELOPMENT (REVIEW)
Текст визуальный непосредственный
Georgian Medical News
Ассоциация деловой прессы Грузии
Вып. 288 С. 125-131
2019
Обзор
anthelmintic agent vaccine animal drug effect helminthiasis human trematode Animals Anthelmintics Helminthiasis Humans Trematoda Vaccines
Helminth infestations, including trematodoses, are a group of the most common diseases in the world. Trematodoses cause significant damage to human health, lead to various complications, which also causes significant economic damage. To develop effective anthelmintic drugs, it is necessary to study the structure and physiology of parasites and interaction with the host body. To create specific anthelmintic drugs, it is necessary to study the features of biochemistry and molecular biology of the structural components of the covers of trematodes. The is important role of the tegument in the evasion of the immune response. The trematode tegument antigens are good candidates for the development of anthelmintic vaccines. It is important to study the trematode genome and identify specific enzyme systems. Proteases of tegument of trematodes are digestive enzymes that can destroy the immunoglobulins of the host to modulate the immune response. Identification of specific differences in protein