Аннотация:
The solubility of ketoprofen (nonsteroidal anti-inflammatory drug) from solid dispersions based on polyvinylpyrrolidone (PVP-10000, PVP-12600 and PVP-24000) is studied. The use of solid dispersions (SDs) increases the solubility and dissolution rate. The solubility of ketoprofen from SD increases by 1.5–2.6 times. The rate of dissolution from SDs increases by 1.5–3.2 times. The studies conducted by a complex of physical and chemical methods suggest that an improved release of ketoprofen from SDs is due to the generation of solid solution of the active substance in the polymer, the formation of intermolecular hydrogen bonds of the active substance with polyvinylpyrrolidone and the solubilizing effect of the polymer during the dissolution of ketoprofen. The results obtained can be used in the development of fast-dissolving solid dosage forms of ketoprofen with enhanced bioavailability. © 2019, Allerton Press, Inc.
Belyatskaya A. V. Anastasiya Vladimirovna 1982-
Krasnyuk I. I. Ivan Ivanovich 1979-
Krasnyuk I. I. Ivan Ivanovich 1955-
Stepanova O. I. Ol`ga Ivanovna 1988-
Abgaryan Zh. A. Zhenya Akopovna 1994-
Yakhyaeva S. T. Saida Telmanovna 1994-
Vorob’yov A. N.
Nesterenko I. S.
Беляцкая А. В. Анастасия Владимировна 1982-
Краснюк И. И. Иван Иванович 1979-
Краснюк И. И. Иван Иванович 1955-
Степанова О. И. Ольга Ивановна 1988-
Абгарян Ж. А. Женя Акоповна 1994-
Яхяева С. Т. Саида Телмановна 1994-
Вороб’ёв А. Н.
Нестеренко И. С.
Study on the Solubility of Ketoprofen From Solid Dispersions with Polyvinylpyrrolidone
Текст визуальный непосредственный
Moscow University Chemistry Bulletin
Allerton Press
Vol.74, Issue2 P. 93-99
2019
Статья
ketoprofen polyvinylpyrrolidone solid dispersions solubility
The solubility of ketoprofen (nonsteroidal anti-inflammatory drug) from solid dispersions based on polyvinylpyrrolidone (PVP-10000, PVP-12600 and PVP-24000) is studied. The use of solid dispersions (SDs) increases the solubility and dissolution rate. The solubility of ketoprofen from SD increases by 1.5–2.6 times. The rate of dissolution from SDs increases by 1.5–3.2 times. The studies conducted by a complex of physical and chemical methods suggest that an improved release of ketoprofen from SDs is due to the generation of solid solution of the active substance in the polymer, the formation of intermolecular hydrogen bonds of the active substance with polyvinylpyrrolidone and the solubilizing effect of the polymer during the dissolution of ketoprofen. The results obtained can be used in the development of fast-dissolving solid dosage forms of ketoprofen with enhanced bioavailability. © 2019, Allerton Press, Inc.