Аннотация:
The review discusses thesteps of vitamin B12 metabolism and its role in maintaining of neurological functions. The term "vitamin B12 (cobalamin)" refers to several substances (cobalamins) of a very similar structure. Cobalamin enters the body with animal products. On the periph-eró cobalamin circulates only in binding with proteins transcobalamin I and II (complex cobalamin-transcobalamin II is designated as “holotranscobalamin”). Holotranscobalamin is absorbed by different cells, whereas transcobalamin I-binded vitamin B12 - only by liver and kidneys. Two forms of cobalamin were identified as coenzymes of cellular reactions which are methylcobalamin (in cytoplasm) and hydrox-yadenosylcobalamin (in mitochondria). The main causes of cobalamin deficiency are related to inadequate intake of animal products, autoimmune gastritis, pancreatic insufficiency, terminal ileum disease, syndrome of intestinal bacterial overgrowth. Relative deficiency may be seen in excessive binding of vitamin B12
Ключевые слова:
Cobalamin; Neurologic manifestations of cobalamin deficiency; Vitamin B12
biological marker; transcobalamin; vitamin B complex; animal; complication; cyanocobalamin deficiency; metabolism; neurologic disease; vitamin deficiency; Animals; Avitaminosis; Biomarkers; Nervous System Diseases; Transcobalamins; Vitamin B 12 Deficiency; Vitamin B Complex
Павлов Ч. С. Чавдар Савов 1967-
Дамулин И. В. Игорь Владимирович 1960-
Шульпекова Ю. О. Юлия Олеговна 1971-
Андреев Е. А. Евгений Андреевич 1997-
Pavlov Ch. S. Chavdar Savov 1967-
Damulin I. V. Igor` Vladimirovich 1960-
Shul`pekova Yu. O. Yuliya Olegovna 1971-
Andreev E. A. Evgenij Andreevich 1997-
Neurological disorders in Vitamin B12 deficiency [Неврологические расстройства при дефиците витамина В12]
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 91, Вып. 4 С. 122-129
2019
Статья
Cobalamin Neurologic manifestations of cobalamin deficiency Vitamin B12
biological marker transcobalamin vitamin B complex animal complication cyanocobalamin deficiency metabolism neurologic disease vitamin deficiency Animals Avitaminosis Biomarkers Nervous System Diseases Transcobalamins Vitamin B 12 Deficiency Vitamin B Complex
The review discusses thesteps of vitamin B12 metabolism and its role in maintaining of neurological functions. The term "vitamin B12 (cobalamin)" refers to several substances (cobalamins) of a very similar structure. Cobalamin enters the body with animal products. On the periph-eró cobalamin circulates only in binding with proteins transcobalamin I and II (complex cobalamin-transcobalamin II is designated as “holotranscobalamin”). Holotranscobalamin is absorbed by different cells, whereas transcobalamin I-binded vitamin B12 - only by liver and kidneys. Two forms of cobalamin were identified as coenzymes of cellular reactions which are methylcobalamin (in cytoplasm) and hydrox-yadenosylcobalamin (in mitochondria). The main causes of cobalamin deficiency are related to inadequate intake of animal products, autoimmune gastritis, pancreatic insufficiency, terminal ileum disease, syndrome of intestinal bacterial overgrowth. Relative deficiency may be seen in excessive binding of vitamin B12