Polymorphous adenocarcinoma of salivary glands
Mimica X., Katabi N., McGill M. R., Hay A., Zanoni D. K., Sha D. P., Wong R. J., Cohen M. A., Patel S. G., Ganly I.
Oral Oncology
Vol.95, P. 52-58
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.oraloncology.2019.06.002
Аннотация:
Objective: Polymorphous adenocarcinoma of salivary gland (PAC) is rare. Despite being described as a low risk histology, some patients develop regional and distant metastasis. More aggressive behavior has been attributed to a PAC subcategory called cribriform adenocarcinoma of minor salivary glands (CAMSG). We examined oncological outcomes of PAC. Patients and methods: Fifty-seven patients with PAC were identified from an institutional database of 884 patients surgically treated for salivary gland malignancies from 1985 to 2015. Detailed histopathological analysis was performed. Survival outcomes were calculated using the Kaplan-Meier method. Factors predictive of recurrence were identified using the Cox proportional hazard method. Results: Fifty-four (95[%]) had tumors of minor salivary gland origin; the most frequent location was the oral cavity in 41 (76[%]), specifically the hard palate in 32 (55[%]). Forty-six patients (81[%]) were clinical T1-T2; 3 (5[%]) had a clinically positive neck. Th
Ключевые слова:
Cribriform adenocarcinoma of minor salivary glands; Minor salivary gland; Polymorphous low-grade adenocarcinoma; Prognosis; Salivary gland neoplasm; Treatment
adult; aged; Article; cancer incidence; cancer radiotherapy; cancer recurrence; cancer staging; cancer survival; cohort analysis; disease specific survival; female; follow up; hard palate; histopathology; human; human tissue; major clinical study; male; mandible resection; maxilla resection; minor saliva gland; mouth carcinoma; mouth cavity; oral surgery; outcome assessment; overall survival; palate disease; parotidectomy; polymorphous adenocarcinoma of salivary gland; postoperative care; priority journal; recurrence free survival; robot assisted surgery; salivary gland; salivary gland carcinoma; very elderly; wide excision; adenocarcinoma; adjuvant radiotherapy; disease free survival; epidemiology; incidence; middle aged; mortality; pathology; prognosis; salivary gland tumor; surgery; surgical margin; time factor; tumor recurrence; young adult; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Disease-Free Survival; Female; Follow-Up Studies; Humans; Incidence; Male; Margins of Excision
Язык текста: Английский
ISSN: 1879-0593
Mimica X.
Katabi N.
McGill M. R.
Hay A.
Zanoni D. K.
Sha D. P. Dzhatin Premanand 1940-
Wong R. J.
Cohen M. A.
Patel S. G.
Ganly I.
Мимиcа Х.
Катаби Н.
МcГилл М. Р.
Хай А.
Занони Д. К.
Ша Д. П. Джатин Премананд 1940-
Wонг Р. Й.
Cохен М. А.
Пател С. Г.
Ганлy И.
Polymorphous adenocarcinoma of salivary glands
Текст визуальный непосредственный
Oral Oncology
Elsevier Science Publisher B.V.
Vol.95 P. 52-58
2019
Статья
Cribriform adenocarcinoma of minor salivary glands Minor salivary gland Polymorphous low-grade adenocarcinoma Prognosis Salivary gland neoplasm Treatment
adult aged Article cancer incidence cancer radiotherapy cancer recurrence cancer staging cancer survival cohort analysis disease specific survival female follow up hard palate histopathology human human tissue major clinical study male mandible resection maxilla resection minor saliva gland mouth carcinoma mouth cavity oral surgery outcome assessment overall survival palate disease parotidectomy polymorphous adenocarcinoma of salivary gland postoperative care priority journal recurrence free survival robot assisted surgery salivary gland salivary gland carcinoma very elderly wide excision adenocarcinoma adjuvant radiotherapy disease free survival epidemiology incidence middle aged mortality pathology prognosis salivary gland tumor surgery surgical margin time factor tumor recurrence young adult Adenocarcinoma Adult Aged Aged, 80 and over Disease-Free Survival Female Follow-Up Studies Humans Incidence Male Margins of Excision
Objective: Polymorphous adenocarcinoma of salivary gland (PAC) is rare. Despite being described as a low risk histology, some patients develop regional and distant metastasis. More aggressive behavior has been attributed to a PAC subcategory called cribriform adenocarcinoma of minor salivary glands (CAMSG). We examined oncological outcomes of PAC. Patients and methods: Fifty-seven patients with PAC were identified from an institutional database of 884 patients surgically treated for salivary gland malignancies from 1985 to 2015. Detailed histopathological analysis was performed. Survival outcomes were calculated using the Kaplan-Meier method. Factors predictive of recurrence were identified using the Cox proportional hazard method. Results: Fifty-four (95[%]) had tumors of minor salivary gland origin; the most frequent location was the oral cavity in 41 (76[%]), specifically the hard palate in 32 (55[%]). Forty-six patients (81[%]) were clinical T1-T2; 3 (5[%]) had a clinically positive neck. Th