Relationship between polymorphism in NOS3, AGTR1, TLR9, DRD4 genes and severity of congenital pneumonia in newborns [ВЛИЯНИЕ ПОЛИМОРФИЗМА ГЕНОВ...
Ионов О. В., Донников А. Е., Безлепкина М. Б., Никитина И. В., Балашов Е. Н., Киртбая А. Р., Крючко Д. С., Баибарина Е. Н.
Акушерство и гинекология
Т. 2019, Вып. 5, С. 102-111
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.18565/aig.2019.5.102-111
Аннотация:
Objective. To identify variable region gene polymorphisms associated with the severity of congenital pneumonia in newborns. Material and Methods. The study comprised 101 newborns with confirmed congenital pneumonia requiring respiratory support after birth. The infants were divided into three groups. Group I (n = 63) included newborns whose respiratory therapy was limited to nasal non-invasive support including CPAP or non-invasive mechanical ventilation in the bi-level CPAP (Biphasic) mode. Newborns in group II (n = 25) required endotracheal intubation and invasive ventilation. Group III (n = 13) included newborns requiring aggressive invasive ventilation (МАР > 12 Н2O и FiO2 > 0.5) and high-frequency oscillatory ventilation (HFOV). All patients were genotyped to identify DNA polymorphism is specific loci. Results. We identified a statistically significant association between the polymorphic locus of the NOS3 gene: -786 (р = 0.028), the AGTR1 polymorphic locus: 1166 A>C (p =
Ключевые слова:
Congenital pneumonia; CPAP; Gene polymorphism; High-frequency oscillatory ventilation (HFOV); Newborn
endothelial nitric oxide synthase; toll like receptor 9; agtr1 gene; air conditioning; Article; artificial ventilation; assisted ventilation; bi level positive end expiratory pressure; disease severity; DNA polymorphism; drd4 gene; gene; gene interaction; genotype; high frequency oscillatory ventilation; human; major clinical study; neonatal pneumonia; newborn; polymorphic locus; positive end expiratory pressure; predictive value
Язык текста: Русский
ISSN: 0300-9092
Ионов О. В. Олег Вадимович 1971-
Донников А. Е.
Безлепкина М. Б.
Никитина И. В.
Балашов Е. Н.
Киртбая А. Р. Анна Ревазиевна 1981-
Крючко Д. С.
Баибарина Е. Н.
Ionov O. V. Oleg Vadimovich 1971-
Donnikov A. E.
Bezlepkina M. B.
Nikitina I. V.
Balashov E. N.
Kirtbaya A. R. Anna Revazievna 1981-
Kryuchko D. S.
Baibarina E. N.
Relationship between polymorphism in NOS3, AGTR1, TLR9, DRD4 genes and severity of congenital pneumonia in newborns [ВЛИЯНИЕ ПОЛИМОРФИЗМА ГЕНОВ NOS3, AGTR1, TLR9, DRD4 НА ТЯЖЕСТЬ ТЕЧЕНИЯ ВРОЖДЕННОЙ ПНЕВМОНИИ У НОВОРОЖДЕННЫХ ДЕТЕЙ]
Relationship between polymorphism in NOS3, AGTR1, TLR9, DRD4 genes and severity of congenital pneumonia in newborns [ВЛИЯНИЕ ПОЛИМОРФИЗМА ГЕНОВ...
Текст визуальный непосредственный
Акушерство и гинекология
Бионика Медиа
Т. 2019, Вып. 5 С. 102-111
2019
Статья
Congenital pneumonia CPAP Gene polymorphism High-frequency oscillatory ventilation (HFOV) Newborn
endothelial nitric oxide synthase toll like receptor 9 agtr1 gene air conditioning Article artificial ventilation assisted ventilation bi level positive end expiratory pressure disease severity DNA polymorphism drd4 gene gene gene interaction genotype high frequency oscillatory ventilation human major clinical study neonatal pneumonia newborn polymorphic locus positive end expiratory pressure predictive value
Objective. To identify variable region gene polymorphisms associated with the severity of congenital pneumonia in newborns. Material and Methods. The study comprised 101 newborns with confirmed congenital pneumonia requiring respiratory support after birth. The infants were divided into three groups. Group I (n = 63) included newborns whose respiratory therapy was limited to nasal non-invasive support including CPAP or non-invasive mechanical ventilation in the bi-level CPAP (Biphasic) mode. Newborns in group II (n = 25) required endotracheal intubation and invasive ventilation. Group III (n = 13) included newborns requiring aggressive invasive ventilation (МАР > 12 Н2O и FiO2 > 0.5) and high-frequency oscillatory ventilation (HFOV). All patients were genotyped to identify DNA polymorphism is specific loci. Results. We identified a statistically significant association between the polymorphic locus of the NOS3 gene: -786 (р = 0.028), the AGTR1 polymorphic locus: 1166 A>C (p =