Аннотация:
The prevalence of ischemic heart disease (IHD) and diabetes mellitus type 2 (DM type 2) is permanently increasing both worldwide and in theRussian Federation. That is why studies of mechanisms of pathogenesis of both diseases is continuing for prevention of complications and mortality. DM type 2 contributes a lot to deterioration of IHD. One of pathogenetic features these two pathologies share is pronounced blood vessel wall fibrosis. In this review we present analysis of studies devoted to the determination of the role of metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 indevelopment of vascular wall fibrosis.
Ключевые слова:
gelatinase B; metalloproteinase; MMP9 protein, human; TIMP1 protein, human; tissue inhibitor of metalloproteinase 1; heart muscle ischemia; human; non insulin dependent diabetes mellitus; Diabetes Mellitus, Type 2; Humans; Matrix Metalloproteinase 9; Metalloproteases; Myocardial Ischemia; Tissue Inhibitor of Metalloproteinase-1
Беленков Ю. Н. Юрий Никитич 1948-
Привалова Е. В. Елена Витальевна 1958-
Иусупова А. О.
Жито А. В. Алексей Владимирович 1993-
Belenkov Yu. N. Yurij Nikitich 1948-
Privalova E. V. Elena Vitalyevna 1958-
Iusupova A. O.
Zhito A. V. Aleksej Vladimirovich 1993-
Markers of Vascular Wall Fibrosis Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinases-1 in Patients with Ischemic Heart Disease with and without Concomitant Type-2 Diabetes Mellitus
Markers of Vascular Wall Fibrosis Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinases-1 in Patients with Ischemic Heart Disease with and...
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Т. 59, Вып. 5 С. 61-66
2019
Статья
gelatinase B metalloproteinase MMP9 protein, human TIMP1 protein, human tissue inhibitor of metalloproteinase 1 heart muscle ischemia human non insulin dependent diabetes mellitus Diabetes Mellitus, Type 2 Humans Matrix Metalloproteinase 9 Metalloproteases Myocardial Ischemia Tissue Inhibitor of Metalloproteinase-1
The prevalence of ischemic heart disease (IHD) and diabetes mellitus type 2 (DM type 2) is permanently increasing both worldwide and in theRussian Federation. That is why studies of mechanisms of pathogenesis of both diseases is continuing for prevention of complications and mortality. DM type 2 contributes a lot to deterioration of IHD. One of pathogenetic features these two pathologies share is pronounced blood vessel wall fibrosis. In this review we present analysis of studies devoted to the determination of the role of metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 indevelopment of vascular wall fibrosis.