Transforming growth factor beta in human milk and allergic outcomes in children: A systematic review
Khaleva E., Gridneva Z., Geddes D. T., Oddy W. H., Colicino S., Blyuss O., Boyle R. J., Warner J. O., Munblit D. B.
Clinical & Experimental Allergy
Vol.49, Issue9, P. 1201-1213
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
Background: Human milk (HM) transforming growth factor beta (TGF-β) is critical for inflammation regulation and oral tolerance promotion. Previous reports suggested that variations in HM TGF-β levels are associated with allergic outcomes. Objective: We undertook a systematic review (PROSPERO 2017 CRD42017069920) to reassess the evidence on the relationships between HM TGF-β and allergic outcomes in children. Methods: Electronic bibliographic databases (MEDLINE, EMBASE and Cochrane Library) were systematically searched. Two independent reviewers screened reference lists, extracted the data and assessed risk of bias using the National Institute for Clinical Excellence methodological checklist. Results: A total of 21 studies were identified. Sixteen studies assessed relationships between HM TGF-β and risk of eczema; 14, allergic sensitization; nine, wheezing/asthma; six, food allergy; three, allergic rhinitis/conjunctivitis. Five cohorts (5/18, 28[%]) reported a protective effect of TGF-β1,
Ключевые слова:
allergic diseases; allergic sensitization; allergy; atopy; breast milk; breastfeeding; colostrum; human milk; transforming growth factor beta
transforming growth factor beta; milk protein; TGFB1 protein, human; TGFB2 protein, human; transforming growth factor beta1; transforming growth factor beta2; allergic rhinitis; allergy; Article; asthma; breast milk; child; Cochrane Library; conjunctivitis; eczema; Embase; food allergy; human; Medline; meta analysis; outcome assessment; priority journal; sensitization; systematic review; wheezing; breast milk; female; immunology; infant; male; milk allergy; newborn; pathology; Female; Humans; Infant; Infant, Newborn; Male; Milk Hypersensitivity; Milk Proteins; Milk, Human; Transforming Growth Factor beta1; Transforming Growth Factor beta2
Язык текста: Английский
ISSN: 1365-2222
Khaleva E.
Gridneva Z.
Geddes D. T.
Oddy W. H.
Colicino S.
Blyuss O. Oleg 1985-
Boyle R. J.
Warner J. O.
Munblit D. B. Daniil Borisovich 1980-
Халева Е.
Гриднева З.
Геддес Д. Т.
Оддy W. Х.
Cолиcино С.
Блюсс О. Олег 1985-
Боyле Р. Й.
Wарнер Й. О.
Мунблит Д. Б. Даниил Борисович 1980-
Transforming growth factor beta in human milk and allergic outcomes in children: A systematic review
Текст визуальный непосредственный
Clinical & Experimental Allergy
John Wiley & Sons, Inc.
Vol.49, Issue9 P. 1201-1213
2019
Статья
allergic diseases allergic sensitization allergy atopy breast milk breastfeeding colostrum human milk transforming growth factor beta
transforming growth factor beta milk protein TGFB1 protein, human TGFB2 protein, human transforming growth factor beta1 transforming growth factor beta2 allergic rhinitis allergy Article asthma breast milk child Cochrane Library conjunctivitis eczema Embase food allergy human Medline meta analysis outcome assessment priority journal sensitization systematic review wheezing breast milk female immunology infant male milk allergy newborn pathology Female Humans Infant Infant, Newborn Male Milk Hypersensitivity Milk Proteins Milk, Human Transforming Growth Factor beta1 Transforming Growth Factor beta2
Background: Human milk (HM) transforming growth factor beta (TGF-β) is critical for inflammation regulation and oral tolerance promotion. Previous reports suggested that variations in HM TGF-β levels are associated with allergic outcomes. Objective: We undertook a systematic review (PROSPERO 2017 CRD42017069920) to reassess the evidence on the relationships between HM TGF-β and allergic outcomes in children. Methods: Electronic bibliographic databases (MEDLINE, EMBASE and Cochrane Library) were systematically searched. Two independent reviewers screened reference lists, extracted the data and assessed risk of bias using the National Institute for Clinical Excellence methodological checklist. Results: A total of 21 studies were identified. Sixteen studies assessed relationships between HM TGF-β and risk of eczema; 14, allergic sensitization; nine, wheezing/asthma; six, food allergy; three, allergic rhinitis/conjunctivitis. Five cohorts (5/18, 28[%]) reported a protective effect of TGF-β1,