Markers of stem cells and their prognostic values for urothelial carcinomas of the urinary tract
Османов Ю. И. О., Коган Е. А., Рапопорт Л. М., Теодорович О. В., Гаибов Й. А.
Урология
Т. 2019, Вып. 2, С. 40-49
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.18565/urology.2019.2.40-49
Аннотация:
The fundamental question about the origin of cancer stem cells of urothelial carcinomas with luminal remains open. So far, no convincing evidence has been found to determine whether these events occur in a single cell, presumably basal, or are realized in different precursor cells of the urothelium. The potential of a number of potential stem markers as cancer stem cells in urothelial carcinomas and their prognostic significance are currently being investigated. Aim. Our aim was to carry out a comparative analysis of the expression of stem markers in the molecular subtypes of urothelial carcinomas, including ALDH1A1, CXCR4, CD24, CD82, CD105, CD133, NANOG, OCT4 and SOX-2. In addition, the relationship between the pattern of expression and the pathological features of the tumor was determined. Patients and methods. Surgical specimens from 196 patients with a diagnosis of urothelial carcinoma of the renal pelvis and bladder were studied. Immunohistochemical study was performed on paraffi
Ключевые слова:
Cancer stem cells; Intratumoral heterogeneity; Urothelial carcinoma
tumor marker; biosynthesis; cancer stem cell; human; immunohistochemistry; metabolism; pathology; prognosis; transitional cell carcinoma; urinary tract tumor; urothelium; Biomarkers, Tumor; Carcinoma, Transitional Cell; Humans; Immunohistochemistry; Neoplastic Stem Cells; Prognosis; Urologic Neoplasms; Urothelium
Язык текста: Русский
ISSN: 1728-2985
Османов Ю. И. О. Юсиф Ислам Оглы 1975-
Коган Е. А. Евгения Алтаровна 1951-
Рапопорт Л. М. Леонид Моисеевич 1956-
Теодорович О. В.
Гаибов Й. А.
Osmanov Yu. I. O. Yusif Islam Ogly' 1975-
Kogan E. A. Evgeniya Altarovna 1951-
Rapoport L. M. Leonid Moiseevich 1956-
Teodorovich O. V.
Gaibov J. A.
Markers of stem cells and their prognostic values for urothelial carcinomas of the urinary tract
Текст визуальный непосредственный
Урология
Бионика Медиа
Т. 2019, Вып. 2 С. 40-49
2019
Статья
Cancer stem cells Intratumoral heterogeneity Urothelial carcinoma
tumor marker biosynthesis cancer stem cell human immunohistochemistry metabolism pathology prognosis transitional cell carcinoma urinary tract tumor urothelium Biomarkers, Tumor Carcinoma, Transitional Cell Humans Immunohistochemistry Neoplastic Stem Cells Prognosis Urologic Neoplasms Urothelium
The fundamental question about the origin of cancer stem cells of urothelial carcinomas with luminal remains open. So far, no convincing evidence has been found to determine whether these events occur in a single cell, presumably basal, or are realized in different precursor cells of the urothelium. The potential of a number of potential stem markers as cancer stem cells in urothelial carcinomas and their prognostic significance are currently being investigated. Aim. Our aim was to carry out a comparative analysis of the expression of stem markers in the molecular subtypes of urothelial carcinomas, including ALDH1A1, CXCR4, CD24, CD82, CD105, CD133, NANOG, OCT4 and SOX-2. In addition, the relationship between the pattern of expression and the pathological features of the tumor was determined. Patients and methods. Surgical specimens from 196 patients with a diagnosis of urothelial carcinoma of the renal pelvis and bladder were studied. Immunohistochemical study was performed on paraffi