From mouth to brain: Neuroendocrine markers play as a crosstalk among oral and neurodegenerative diseases
Tatullo M., Codispoti B., Makeeva I. M., Benincasa C., Spanyuolo D.
Frontiers in Endocrinology
Vol.10, Num.378
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.3389/fendo.2019.00378
Аннотация:
The neuroendocrine system consists of various cells distributed in non-endocrine functional structures, able to synthesize amines and peptides with both local (paracrine) and systemic (endocrine) effects. The presence of such cells, belonging to the neuroendocrine system, is highlighted by the presence of neuroendocrine markers: the most suggestive are chromogranin A, synaptophysin, S-100B protein and glial fibrillary acidic protein. The presence of neuroendocrine markers is commonly associated to the occurrence of neuroendocrine cancers, currently representing the 0.5 percent of all malignant tumors. Nevertheless, neuroendocrine markers have been found to be overexpressed in rare oral neuroendocrine tumors, but also in quite common inflammatory conditions, such as severe periodontitis. The monitoring of neuroendocrine markers is, thus, a common factor of interest among dentistry and neurology: the analysis of neuroendocrine markers in oral diseases may be predictive and prognostic abo
Ключевые слова:
Early diagnosis; Neuroendocrine cancer; Oral cancer; Predictive markers; Predictive medicine
chromogranin A; epidermal growth factor receptor; glial fibrillary acidic protein; neuron specific enolase; peripherin; protein S100B; synaptophysin; Alzheimer disease; amyotrophic lateral sclerosis; Article; cognitive defect; degenerative disease; human; immunoelectron microscopy; immunohistochemistry; immunoreactivity; mouth cancer; mouth disease; neuroendocrine carcinoma; neuroendocrine system; neuroendocrine tumor; neurologic disease; periodontitis; protein expression; traumatic brain injury; Western blotting
Язык текста: Английский
ISSN: 1664-2392
Tatullo M. Marko 1978-
Codispoti B.
Makeeva I. M. Irina Mikhaylovna 1963-
Benincasa C.
Spanyuolo D. Dzhanriko 1972-
Татулло М. Марко 1978-
Cодиспоти Б.
Макеева И. М. Ирина Михайловна 1963-
Бенинcаса C.
Спанюоло Д. Джанрико 1972-
From mouth to brain: Neuroendocrine markers play as a crosstalk among oral and neurodegenerative diseases
Текст визуальный непосредственный
Frontiers in Endocrinology
Vol.10 Num.378
2019
Статья
Early diagnosis Neuroendocrine cancer Oral cancer Predictive markers Predictive medicine
chromogranin A epidermal growth factor receptor glial fibrillary acidic protein neuron specific enolase peripherin protein S100B synaptophysin Alzheimer disease amyotrophic lateral sclerosis Article cognitive defect degenerative disease human immunoelectron microscopy immunohistochemistry immunoreactivity mouth cancer mouth disease neuroendocrine carcinoma neuroendocrine system neuroendocrine tumor neurologic disease periodontitis protein expression traumatic brain injury Western blotting
The neuroendocrine system consists of various cells distributed in non-endocrine functional structures, able to synthesize amines and peptides with both local (paracrine) and systemic (endocrine) effects. The presence of such cells, belonging to the neuroendocrine system, is highlighted by the presence of neuroendocrine markers: the most suggestive are chromogranin A, synaptophysin, S-100B protein and glial fibrillary acidic protein. The presence of neuroendocrine markers is commonly associated to the occurrence of neuroendocrine cancers, currently representing the 0.5 percent of all malignant tumors. Nevertheless, neuroendocrine markers have been found to be overexpressed in rare oral neuroendocrine tumors, but also in quite common inflammatory conditions, such as severe periodontitis. The monitoring of neuroendocrine markers is, thus, a common factor of interest among dentistry and neurology: the analysis of neuroendocrine markers in oral diseases may be predictive and prognostic abo