Clinical and laboratory characteristics of IgG4-realated disease and its diagnostic algorithm [Клинико-лабораторная характеристика IgG4-связанного...
Сокол Е. В., Васильев В. И., Палшина С. Г., Кокосадзе Н. В., Пробатова Н. А., Ковригина А. М., Сафонова Т. Н., Родионова Е. Б., Гаидук И. В., Селифанова Е. И.
Терапевтический архив
Т. 91, Вып. 5, С. 40-48
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.26442/00403660.2019.05.000236
Аннотация:
Aim: to propose diagnostic algorithm of IgG4-related disease (IgG4-RD). Materials and methods. One center retrospective research. 52 pts with IgG4-RD were included. The diagnosis was proved histologically and immunohistochemically. 48 out of 52 pts received treatment. Treatment included one of the following schemes (along with low oral glucocorticoids): rituximab monotherapy, cyclophosphamide monotherapy or their combination. Results. The mean age was 47.4±5.9 years, the mean age of the disease onset was 43.9±16.0 years. Median time before the diagnosis was 24 months. The most often sites of IgG4-RD were lacrimal (63.5[%]), salivary (46.2[%]) glands, lungs (48[%]), lymph nodes (34.6[%]) and retroperitoneum (17.3[%]). In clinical picture the leading complain was organ enlargement, but not its dysfunction. Pain was characteristic for retroperitoneum localization. In 56.8[%] of pts with IgG4-related syalo- and/or dacryoadenitis there was association with ear-nose-throat organs affection. In 4 pts (7.
Ключевые слова:
Diagnostic algorithm; IgG4-related dacryoadenitis; IgG4-related disease; IgG4-related sialoadenitis; MALT-lymphoma; Monoclonal secretion; Retroperitoneal fibrosis
immunoglobulin G; rituximab; adult; algorithm; diagnosis; human; middle aged; retrospective study; therapy; Adult; Algorithms; Humans; Immunoglobulin G; Immunoglobulin G4-Related Disease; Middle Aged; Retrospective Studies; Rituximab
Язык текста: Русский
ISSN: 2309-5342
Сокол Е. В.
Васильев В. И.
Палшина С. Г.
Кокосадзе Н. В.
Пробатова Н. А.
Ковригина А. М.
Сафонова Т. Н.
Родионова Е. Б.
Гаидук И. В.
Селифанова Е. И.
Sokol E. V.
Vasilyev V. I.
Palshina S. G.
Kokosadze N. V.
Probatova N. A.
Kovrigina A. M.
Safonova T. N.
Rodionova E. B.
Gaiduk I. V.
Selifanova E. I.
Clinical and laboratory characteristics of IgG4-realated disease and its diagnostic algorithm [Клинико-лабораторная характеристика IgG4-связанного заболевания и алгоритм его диагностики]
Clinical and laboratory characteristics of IgG4-realated disease and its diagnostic algorithm [Клинико-лабораторная характеристика IgG4-связанного...
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 91, Вып. 5 С. 40-48
2019
Статья
Diagnostic algorithm IgG4-related dacryoadenitis IgG4-related disease IgG4-related sialoadenitis MALT-lymphoma Monoclonal secretion Retroperitoneal fibrosis
immunoglobulin G rituximab adult algorithm diagnosis human middle aged retrospective study therapy Adult Algorithms Humans Immunoglobulin G Immunoglobulin G4-Related Disease Middle Aged Retrospective Studies Rituximab
Aim: to propose diagnostic algorithm of IgG4-related disease (IgG4-RD). Materials and methods. One center retrospective research. 52 pts with IgG4-RD were included. The diagnosis was proved histologically and immunohistochemically. 48 out of 52 pts received treatment. Treatment included one of the following schemes (along with low oral glucocorticoids): rituximab monotherapy, cyclophosphamide monotherapy or their combination. Results. The mean age was 47.4±5.9 years, the mean age of the disease onset was 43.9±16.0 years. Median time before the diagnosis was 24 months. The most often sites of IgG4-RD were lacrimal (63.5[%]), salivary (46.2[%]) glands, lungs (48[%]), lymph nodes (34.6[%]) and retroperitoneum (17.3[%]). In clinical picture the leading complain was organ enlargement, but not its dysfunction. Pain was characteristic for retroperitoneum localization. In 56.8[%] of pts with IgG4-related syalo- and/or dacryoadenitis there was association with ear-nose-throat organs affection. In 4 pts (7.