Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
Tereshchenko O. G., Nikolskaya E. D., Zhunina O. A., Zavarzina V. V., Yabbarov N. G., Fomicheva M. V., Zubkov E. V., Sokol M. B., Gukasova N. V., Severin E. S.
Russian Chemical Bulletin
Vol.67, Issue12, P. 2290-2296
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1007/s11172-018-2372-4
Аннотация:
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
hepatoprotectors; poly(lactic-co-glycolic acid); polymeric particles; silybin; ursodeoxycholic acid
Язык текста: Английский
ISSN: 1573-9171
Tereshchenko O. G.
Nikolskaya E. D.
Zhunina O. A.
Zavarzina V. V.
Yabbarov N. G.
Fomicheva M. V.
Zubkov E. V.
Sokol M. B.
Gukasova N. V.
Severin E. S. Evgenij Sergeevich 1934-
Терешченко О. Г.
Николскайа Е. Д.
Жунина О. А.
Заварзина В. В.
Яббаров Н. Г.
Фомичева М. В.
Зубков Е. В.
Сокол М. Б.
Гукасова Н. В.
Северин Е. С. Евгений Сергеевич 1934-
Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
Текст визуальный непосредственный
Russian Chemical Bulletin
Springer-Verlag GmbH
Vol.67, Issue12 P. 2290-2296
2018
Статья
hepatoprotectors poly(lactic-co-glycolic acid) polymeric particles silybin ursodeoxycholic acid
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.