Аннотация:
The possibility that binuclear dinitrosyl iron complexes with glutathione and cysteine (DNIC-GSН and B-DNIC-Cys) have a strong cytotoxic effect on the growth of endometrioid tumours (EMT) in rats with surgically induced experimental endometriosis established in our previous studies has been supported with experimental data. The increase in the DNIC-GSН or B-DNIC-Cys dose from 10 (in our previous studies) to 20 μmol/kg (after i/p administration to experimental rats) fully suppressed the growth of uterine tissues implanted onto the inner surface of the abdominal wall. At 2 μmol/kg DNIC-GSН, the median value of EMT volume increased from 0 to 15 mm 3 , while the mean size of EMT—from 55 to 77 mm 3 (data from EMT measurements in 10 experimental rats). After treatment of animals with B-DNIC with N-acetyl-L-cysteine (10 μmol/kg) known for its ability to penetrate easily through the cell membrane, the inhibiting effect on EMT growth diminished as could be evidenced from the transformation of ~
Ключевые слова:
Dinitrosyl iron complexes; Endometriosis; Nitric oxide
coordination compound; cysteine; dinitrosyl iron complex; glutathione; iron; ligand; nitric oxide; nitrogen oxide; thiol derivative; animal; chemistry; disease model; electron spin resonance; endometriosis; female; metabolism; pathology; rat; Wistar rat; Animals; Coordination Complexes; Cysteine; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Endometriosis; Female; Glutathione; Iron; Ligands; Nitric Oxide; Nitrogen Oxides; Rats; Rats, Wistar; Sulfhydryl Compounds
Бургова Е. Н.
Khristidis Y. I.
Kurkov A. V. Aleksandr Vitalyevich 1989-
Mikoyan V. D.
Shekhter A. B. Anatolij Borukhovich 1933-
Adamyan L. V.
Timashev P. S. Petr Sergeevich 1978-
Vanin A. F. Anatolij Fedorovich 1938-
Burgova E. N.
Христидис Y. И.
Курков А. В. Александр Витальевич 1989-
Микоян В. Д.
Шехтер А. Б. Анатолий Борухович 1933-
Адамян Л. В.
Тимашев П. С. Петр Сергеевич 1978-
Ванин А. Ф. Анатолий Федорович 1938-
The Inhibiting Effect of Dinitrosyl Iron Complexes with Thiol-containing Ligands on the Growth of Endometrioid Tumours in Rats with Experimental Endometriosis
The Inhibiting Effect of Dinitrosyl Iron Complexes with Thiol-containing Ligands on the Growth of Endometrioid Tumours in Rats with Experimental...
Текст визуальный непосредственный
Cell Biochemistry and Biophysics
Humana Press, Inc.
Vol.77, Issue1 P. 69-77
2019
Статья
Dinitrosyl iron complexes Endometriosis Nitric oxide
coordination compound cysteine dinitrosyl iron complex glutathione iron ligand nitric oxide nitrogen oxide thiol derivative animal chemistry disease model electron spin resonance endometriosis female metabolism pathology rat Wistar rat Animals Coordination Complexes Cysteine Disease Models, Animal Electron Spin Resonance Spectroscopy Endometriosis Female Glutathione Iron Ligands Nitric Oxide Nitrogen Oxides Rats Rats, Wistar Sulfhydryl Compounds
The possibility that binuclear dinitrosyl iron complexes with glutathione and cysteine (DNIC-GSН and B-DNIC-Cys) have a strong cytotoxic effect on the growth of endometrioid tumours (EMT) in rats with surgically induced experimental endometriosis established in our previous studies has been supported with experimental data. The increase in the DNIC-GSН or B-DNIC-Cys dose from 10 (in our previous studies) to 20 μmol/kg (after i/p administration to experimental rats) fully suppressed the growth of uterine tissues implanted onto the inner surface of the abdominal wall. At 2 μmol/kg DNIC-GSН, the median value of EMT volume increased from 0 to 15 mm 3 , while the mean size of EMT—from 55 to 77 mm 3 (data from EMT measurements in 10 experimental rats). After treatment of animals with B-DNIC with N-acetyl-L-cysteine (10 μmol/kg) known for its ability to penetrate easily through the cell membrane, the inhibiting effect on EMT growth diminished as could be evidenced from the transformation of ~