Decellularized cadaveric human artery for substitution of connective tissue and smooth muscle defects on the example of tunica albuginea of penis...
Забелин М. В., Кyзласов П. С., Трояков В. М., Паклина О. В., Сетдикова Г. Р., Самчук Д. П., Кажера А. А., Ачкасов Е. Е.
Хирургия. Журнал им. Н.И. Пирогова
Вып. 1, С. 43-49
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.17116/hirurgia201901143
Аннотация:
AIM: To analyze experimentally the outcomes of xenotransplantation (cadaveric artery, decellularized cadaveric artery) for tunica albuginea defects repair. MATERIAL AND METHODS: The study included 60 chinchilla rabbits. Rabbits underwent local replacement of tunica albuginea. Animals were divided into 2 groups (group 1 - human cadaveric artery, group 2 - decellularized cadaveric artery). The result was considered after 7, 14 and 30 days postoperatively. RESULTS: Tendency to stasis, sludge-phenomenon and ultimately development of fibrosis of transplantation area were histologically observed in group 1 after 30 days. In group 2 luminal surface of decellularized artery was smoothed, fibrin and blood elements were absent. In group 1 mean level of C-reactive protein was 3.86±0.43, 1.17±0.2 and 0.73±0.16 mg/L after 7, 14 and 30 days respectively. In group 2 the same values were 0.33±0.03, 0.23±0.03 and 0.11±0.02 mg/L. Differences were significant (t =-46.28, t = -25.95, t = -14.84; p<0.0001)
Ключевые слова:
cadaver artery; decellularized artery; xenotransplantation
animal; artery; cadaver; connective tissue; human; injuries; injury; Leporidae; male; pathology; penis; procedures; smooth muscle; transplantation; vascularization; xenograft; Animals; Arteries; Cadaver; Connective Tissue; Humans; Male; Muscle, Smooth; Penis; Rabbits; Transplantation, Heterologous; Wounds and Injuries
Язык текста: Русский
ISSN: 2309-5628
Забелин М. В.
Кyзласов П. С.
Трояков В. М.
Паклина О. В.
Сетдикова Г. Р.
Самчук Д. П.
Кажера А. А.
Ачкасов Е. Е. Евгений Евгеньевич 1974-
Zabelin M. V.
Kyzlasov P. S.
Troyakov V. M.
Paklina O. V.
Setdikova G. R.
Samchuk D. P.
Kazhera A. A.
Achkasov E. E. Evgenij Evgenyevich 1974-
Decellularized cadaveric human artery for substitution of connective tissue and smooth muscle defects on the example of tunica albuginea of penis (experimental work) [Ispol'zovanie detselliuliarizirovannoĭ trupnoĭ arterii cheloveka dlia zameshcheniia defektov soedinitel'notkannykh i gladkomyshechnykh struktur na primere belochnoĭ obolochki polovogo chlena (éksperimental'naia rabota)]
Decellularized cadaveric human artery for substitution of connective tissue and smooth muscle defects on the example of tunica albuginea of penis...
Текст визуальный непосредственный
Хирургия. Журнал им. Н.И. Пирогова
Издательство Медиа Сфера
Вып. 1 С. 43-49
2019
Статья
cadaver artery decellularized artery xenotransplantation
animal artery cadaver connective tissue human injuries injury Leporidae male pathology penis procedures smooth muscle transplantation vascularization xenograft Animals Arteries Cadaver Connective Tissue Humans Male Muscle, Smooth Penis Rabbits Transplantation, Heterologous Wounds and Injuries
AIM: To analyze experimentally the outcomes of xenotransplantation (cadaveric artery, decellularized cadaveric artery) for tunica albuginea defects repair. MATERIAL AND METHODS: The study included 60 chinchilla rabbits. Rabbits underwent local replacement of tunica albuginea. Animals were divided into 2 groups (group 1 - human cadaveric artery, group 2 - decellularized cadaveric artery). The result was considered after 7, 14 and 30 days postoperatively. RESULTS: Tendency to stasis, sludge-phenomenon and ultimately development of fibrosis of transplantation area were histologically observed in group 1 after 30 days. In group 2 luminal surface of decellularized artery was smoothed, fibrin and blood elements were absent. In group 1 mean level of C-reactive protein was 3.86±0.43, 1.17±0.2 and 0.73±0.16 mg/L after 7, 14 and 30 days respectively. In group 2 the same values were 0.33±0.03, 0.23±0.03 and 0.11±0.02 mg/L. Differences were significant (t =-46.28, t = -25.95, t = -14.84; p<0.0001)