Targeted delivery to tumors: Multidirectional strategies to improve treatment efficiency
Kutova O. M., Guryev E. L., Sokolova E. A., Alzeibak R., Balalaeva I. V.
Cancers
Vol.11, Issue1, Num.68
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.3390/cancers11010068
Аннотация:
Malignant tumors are characterized by structural and molecular peculiarities providing a possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and reduced side effects. Newly formed blood vessels in malignant lesions exhibit chaotic growth, disordered structure, irregular shape and diameter, protrusions, and blind ends, resulting in immature vasculature; the newly formed lymphatic vessels also have aberrant structure. Structural features of the tumor vasculature determine relatively easy penetration of large molecules as well as nanometer-sized particles through a blood-tissue barrier and their accumulation in a tumor tissue. Also, malignant cells have altered molecular profile due to significant changes in tumor cell metabolism at every level from the genome to metabolome. Recently, the tumor interaction with cells of immune system becomes the focus of particular attention, that among others findings resulted in extensive study of cells with prefe
Ключевые слова:
Active targeting; Cancer treatment; Cancer-specific molecular targets; Cell-mediated targeting; EPR-effect; Passive targeting; Targeted drug delivery
brentuximab vedotin; cetuximab; cytarabine; daunorubicin; doxorubicin; gemcitabine; inotuzumab ozogamicin; irinotecan; irinotecan sucrosofate; lorvotuzumab mertansine; mifamurtide; paclitaxel; trastuzumab; vincristine; vincristine sulfate; clinical feature; drug delivery system; drug effect; drug efficacy; drug response; enhanced permeability and retention effect; human; molecularly targeted therapy; neoplasm; nonhuman; pharmaceutics; Review; treatment outcome; tumor vascularization
Язык текста: Английский
ISSN: 2072-6694
Kutova O. M.
Guryev E. L.
Sokolova E. A.
Alzeibak R.
Balalaeva I. V. Irina Vladimirovna 1978-
Кутова О. М.
Гурьев Е. Л.
Соколова Е. А.
Алзеибак Р.
Балалаева И. В. Ирина Владимировна 1978-
Targeted delivery to tumors: Multidirectional strategies to improve treatment efficiency
Текст визуальный непосредственный
Cancers
Vol.11, Issue1 Num.68
2019
Обзор
Active targeting Cancer treatment Cancer-specific molecular targets Cell-mediated targeting EPR-effect Passive targeting Targeted drug delivery
brentuximab vedotin cetuximab cytarabine daunorubicin doxorubicin gemcitabine inotuzumab ozogamicin irinotecan irinotecan sucrosofate lorvotuzumab mertansine mifamurtide paclitaxel trastuzumab vincristine vincristine sulfate clinical feature drug delivery system drug effect drug efficacy drug response enhanced permeability and retention effect human molecularly targeted therapy neoplasm nonhuman pharmaceutics Review treatment outcome tumor vascularization
Malignant tumors are characterized by structural and molecular peculiarities providing a possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and reduced side effects. Newly formed blood vessels in malignant lesions exhibit chaotic growth, disordered structure, irregular shape and diameter, protrusions, and blind ends, resulting in immature vasculature; the newly formed lymphatic vessels also have aberrant structure. Structural features of the tumor vasculature determine relatively easy penetration of large molecules as well as nanometer-sized particles through a blood-tissue barrier and their accumulation in a tumor tissue. Also, malignant cells have altered molecular profile due to significant changes in tumor cell metabolism at every level from the genome to metabolome. Recently, the tumor interaction with cells of immune system becomes the focus of particular attention, that among others findings resulted in extensive study of cells with prefe